低碳酸酐酶II（CA II）表达与胃癌患者的肿瘤侵袭性及不良预后相关。
Low CA II expression is associated with tumor aggressiveness and poor prognosis in gastric cancer patients.
作者信息
Hu Xiaotong, Huang Zhongting, Liao Zhongcai, He Chao, Fang Xiao
机构信息
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou 30016, Zhejiang, China.
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou 30016, Zhejiang, China ; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 30016, Zhejiang, China.
出版信息
Int J Clin Exp Pathol. 2014 Sep 15;7(10):6716-24. eCollection 2014.
BACKGROUND
Carbonic anhydrase II is present in normal gastric mucosa; thus, this study aimed to investigate whether its expression persisted in neoplastic gastric tissues, as well as its prognostic value for gastric cancer patients.
METHODS
The protein CA II expression pattern was retrospectively analyzed by immunohistochemistry in 181 gastric cancer patients who had undergone gastrectomy. The relationship between the CA II expression level and clinicopathological parameters was investigated. Survival analysis according to CA II expression was measured by Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of CA II expression.
RESULTS
CA II expression was significantly decreased in gastric cancer tissues compared with normal stomach mucosa. Low expression was significantly associated with tumor size, depth of invasion, lymph node involvement, distant metastasis and TNM stage, and it predicted poor survival in gastric cancer patients. Moreover, CA II was an independent prognosis indicator for the overall survival of gastric cancer patients.
CONCLUSIONS
The down-regulation of CA II expression was observed in gastric cancer and may serve as an independent prognostic factor for the overall survival of gastric cancer patients.
背景
碳酸酐酶II存在于正常胃黏膜中；因此，本研究旨在调查其表达在胃肿瘤组织中是否持续存在，以及其对胃癌患者的预后价值。
方法
通过免疫组织化学回顾性分析181例行胃切除术的胃癌患者的蛋白CA II表达模式。研究CA II表达水平与临床病理参数之间的关系。采用Kaplan-Meier分析根据CA II表达进行生存分析。单因素和多因素Cox回归分析用于评估CA II表达的预后价值。
结果
与正常胃黏膜相比，胃癌组织中CA II表达显著降低。低表达与肿瘤大小、浸润深度、淋巴结受累、远处转移和TNM分期显著相关，且提示胃癌患者预后不良。此外，CA II是胃癌患者总生存的独立预后指标。
结论
在胃癌中观察到CA II表达下调，其可能作为胃癌患者总生存的独立预后因素。
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