Eady R P, Jackson D M
Fisons plc Pharmaceutical Division, Research and Development Laboratories, Loughborough, UK.
Int Arch Allergy Appl Immunol. 1989;88(1-2):240-3. doi: 10.1159/000234797.
In anaesthetized dogs exposed to SO2, nedocromil sodium prevented the increase in bronchial responsiveness to histamine challenge and suppressed the cellular changes taking place in the lung. In conscious dogs challenged with citric acid, by inhalation, nedocromil sodium prolonged the time to onset of coughing and had an inhibitory effect on the total number of coughs in each episode. Nedocromil sodium has been observed to stimulate bronchial C fibers, and it is suggested that this activity may relate to the antitussive effect of the compound.
在暴露于二氧化硫的麻醉犬中，奈多罗米钠可防止支气管对组胺激发的反应性增加，并抑制肺内发生的细胞变化。在经柠檬酸吸入激发的清醒犬中，奈多罗米钠可延长咳嗽发作时间，并对每一阵咳嗽的总数产生抑制作用。已观察到奈多罗米钠可刺激支气管C纤维，提示该活性可能与该化合物的镇咳作用有关。
