Pearce F L
Department of Chemistry, University College London, United Kingdom.
J Allergy Clin Immunol. 1993 Jul;92(1 Pt 2):155-8. doi: 10.1016/0091-6749(93)90098-z.
Bronchial asthma is a complex inflammatory disorder that involves activation of, and mediator release by, a variety of cells including mast cells. Nedocromil sodium can inhibit the activity of a range of inflammatory cells including mast cells, as has been demonstrated in several studies. In human beings nedocromil sodium inhibited histamine secretion from mast cells obtained by bronchoalveolar lavage and from dispersed lung mast cells. Tachyphylaxis was noted with the latter cells only. Because the bronchoalveolar lavage mast cells would come into direct contact with inhaled drugs, these cells may be a major target for the action of nedocromil sodium. The inhibitory effects of nedocromil sodium on mast cell activation and secretion are one way the drug may be effective in controlling airway obstruction.
支气管哮喘是一种复杂的炎症性疾病，涉及多种细胞（包括肥大细胞）的激活和介质释放。多项研究已证实，奈多罗米钠可抑制包括肥大细胞在内的一系列炎症细胞的活性。在人体中，奈多罗米钠可抑制通过支气管肺泡灌洗获得的肥大细胞以及分散的肺肥大细胞分泌组胺。仅在后者细胞中观察到快速减敏现象。由于支气管肺泡灌洗肥大细胞会与吸入药物直接接触，这些细胞可能是奈多罗米钠作用的主要靶点。奈多罗米钠对肥大细胞激活和分泌的抑制作用是该药物有效控制气道阻塞的一种方式。
