SEND-PD的独立验证及其与MDS-UPDRS第IA部分的相关性
Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA.
作者信息
Rodríguez-Violante Mayela, Cervantes-Arriaga Amin, Velázquez-Osuna Salvador, Llorens-Arenas Rodrigo, Calderón-Fajardo Humberto, Piña-Fuentes Dan, Martinez-Martin Pablo
机构信息
Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, La Fama, 14269 Mexico City, Mexico ; Movement Disorders Clinic, National Institute of Neurology and Neurosurgery, 14269 Mexico City, Mexico.
Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, La Fama, 14269 Mexico City, Mexico.
出版信息
Parkinsons Dis. 2014;2014:260485. doi: 10.1155/2014/260485. Epub 2014 Oct 23.
Introduction. Neuropsychiatric symptoms in Parkinson's disease can be assessed by the MDS-UPDRS part IA. The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's disease (SEND-PD) has been recently developed to assess the severity of some neuropsychiatric symptoms. The objective of this study is to compare the performance of the SEND-PD with the corresponding items of the MDS-UPDRS part IA. Methods. Patients with Parkinson's disease were evaluated using the MDS-UPDRS and the SEND-PD by independent raters. Partial SEND-PD and neuropsychiatric MDS-UPDRS part IA were constructed with equivalent items for comparison. Results. A total of 260 consecutive patients were included. Overall, 61.2% of the patients did not report any psychotic symptom and 83.5% did not report any ICD symptom. On the other hand, 78.5% of the patients did report at least one symptom related to apathy, depression, or anxiety. The partial SEND-PD score was 2.9 ± 3.1 (range from 0 to 16). The neuropsychiatric MDS-UPDRS part IA score was 2.9 ± 3 (range from 0 to 14). The correlation coefficient between corresponding items ranged from 0.67 to 0.98 and between both summary indexes was r s = 0.93 (all, P < 0.001). Conclusion. A high association between equivalent items of the SEND-PD and the MDS-UPDRS was found.
引言。帕金森病的神经精神症状可通过MDS-UPDRS第一部分A进行评估。帕金森病神经精神障碍评估量表（SEND-PD）最近已被开发出来，用于评估某些神经精神症状的严重程度。本研究的目的是比较SEND-PD与MDS-UPDRS第一部分A相应条目的表现。方法。由独立评估者使用MDS-UPDRS和SEND-PD对帕金森病患者进行评估。构建了具有等效条目的部分SEND-PD和神经精神MDS-UPDRS第一部分A，用于比较。结果。共纳入260例连续患者。总体而言，61.2%的患者未报告任何精神病性症状，83.5%的患者未报告任何国际疾病分类（ICD）症状。另一方面，78.5%的患者确实报告了至少一种与冷漠､抑郁或焦虑相关的症状。部分SEND-PD评分为2.9±3.1（范围为0至16）。神经精神MDS-UPDRS第一部分A评分为2.9±3（范围为0至14）。相应条目之间的相关系数在0.67至0.98之间，两个汇总指标之间的相关系数为rs = 0.93（所有P < 0.001）。结论。发现SEND-PD与MDS-UPDRS的等效条目之间存在高度相关性。
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