Salganik R I, Griaznova I M, Markel' A L, Baginskaia N V
Ontogenez. 1978;9(2):193-7.
The influence of cortisole injections and stress ("handling") in the early ontogenesis (during the first 9 or 16 days of life) on the process of thyrosine aminotransferase induction by cortisol in the adult rats has been studied. It was shown that both the injection of the hormone in the young rats and "handling" led to the manifested trace effects: (1) stable increase of thyrosine aminotransferase activity in the liver of adult (5-6 months) rats and (2) appearance of peculiar tolerance to cortisol in the form of decrease in the ability of cells to induce thyrosine aminotransferase in response to the hormone injection. The data obtained suggest that the sensitive period of postnatal ontogenesis when cortisol or "handling" exert such a stable effect is limited by the 3rd and 9th days after birth. The causes of such "biochemical imprinting" are considered with respect to the increased sensitivity of the genetical system of cells-targets to the transcription inducers during the early postnatal development.
研究了在个体发育早期（出生后的前9天或16天）注射皮质醇和应激（“处理”）对成年大鼠中皮质醇诱导酪氨酸转氨酶过程的影响。结果表明，幼鼠体内注射激素以及“处理”均会产生明显的痕迹效应：（1）成年（5 - 6个月）大鼠肝脏中酪氨酸转氨酶活性稳定增加；（2）细胞对激素注射诱导酪氨酸转氨酶能力下降，从而表现出对皮质醇的特殊耐受性。所得数据表明，皮质醇或“处理”产生这种稳定效应的产后个体发育敏感期受出生后第3天至第9天限制。针对产后早期发育过程中细胞 - 靶标的遗传系统对转录诱导剂敏感性增加的情况，对这种“生化印记”的原因进行了探讨。
