Iakobson G S, Sorokin A S, Gizatulin Z Ia, Shorin Iu P
Vopr Med Khim. 1977 Sep-Oct;23(5):701-3.
Acitivity of tyrosine-alpha-ketoglutarate transaminase and induction of the enzyme by hydro cortisone were studied in rat liver tissue after partial hepatectomy and intoxication with CCl4 Administration of the hormone increased the enzymatic activity within 72 hrs after treatment with CCl4 but did not affect its value within 8 and 24 hrs. Activation of the enzyme by hydrocortisone correlated with the increased enzymatic activity observed within 20 hrs after partial hepatectomy. Possible mechanisms for activation of the enzyme, caused by endo- and exogenous factors, are discussed.
在大鼠肝组织进行部分肝切除及用四氯化碳中毒后，研究了酪氨酸-α-酮戊二酸转氨酶的活性以及氢化可的松对该酶的诱导作用。给予激素后，在四氯化碳处理后72小时内酶活性增加，但在8小时和24小时内对其值无影响。氢化可的松对该酶的激活与部分肝切除后20小时内观察到的酶活性增加相关。讨论了由内源性和外源性因素引起的该酶激活的可能机制。
