Lee Hee Yoon, Marvdashti Tahereh, Duan Lian, Khan Saara A, Ellerbee Audrey K
E.L. Ginzton Laboratory and Department of Electrical Engineering Stanford University, Stanford, CA 94305, USA.
Biomed Opt Express. 2014 Aug 27;5(9):3192-203. doi: 10.1364/BOE.5.003192. eCollection 2014 Sep 1.
We demonstrate highly parallel imaging with interleaved optical coherence tomography (iOCT) using an in-house-fabricated, air-spaced virtually-imaged phased array (VIPA). The air-spaced VIPA performs spectral encoding of the interferograms from multiple lateral points within a single sweep of the source and allows us to tune and balance several imaging parameters: number of multiplexed points, ranging depth, and sensitivity. In addition to a thorough discussion of the parameters and operating principles of the VIPA, we experimentally demonstrate the effect of different VIPA designs on the multiplexing potential of iOCT. Using a 200-kHz light source, we achieve an effective A-scan rate of 3.2-MHz by multiplexing 16 lateral points onto a single wavelength sweep. The improved sensitivity of this system is demonstrated for 3D imaging of biological samples such as a human finger and a fruit fly.
我们展示了使用内部制造的空气间隔虚拟成像相控阵（VIPA）进行的交错光学相干断层扫描（iOCT）的高度并行成像。空气间隔VIPA在光源的单次扫描中对来自多个横向点的干涉图进行光谱编码，并使我们能够调整和平衡几个成像参数：复用点数、测距深度和灵敏度。除了对VIPA的参数和工作原理进行深入讨论外，我们还通过实验证明了不同VIPA设计对iOCT复用潜力的影响。使用200 kHz光源，我们通过在单个波长扫描上复用16个横向点，实现了3.2 MHz的有效A扫描速率。该系统的灵敏度提高在生物样本（如人体手指和果蝇）的三维成像中得到了证明。
