Clemson University, Department of Bioengineering, COMSET, Clemson, South Carolina 29634, USA.
J Biomed Opt. 2011 Jun;16(6):066016. doi: 10.1117/1.3593149.
Here we present an ultrahigh-speed Fourier-domain optical coherence tomography (OCT) that records the OCT spectrum in streak mode with a high-speed area scan camera, which allows higher OCT imaging speed than can be achieved with a line-scan camera. Unlike parallel OCT techniques that also use area scan cameras, the conventional single-mode fiber-based point-scanning mechanism is retained to provide a confocal gate that rejects multiply scattered photons from the sample. When using a 1000 Hz resonant scanner as the streak scanner, 1,016,000 A-scans have been obtained in 1 s. This method's effectiveness has been demonstrated by recording in vivo OCT-image sequences of embryonic chick hearts at 1000 frames/s. In addition, 2-megahertz OCT data have been obtained with another high speed camera.
我们在此介绍一种超高速傅里叶域光学相干断层扫描（OCT）系统，该系统使用高速面阵相机以条纹模式记录 OCT 光谱，从而实现比线扫描相机更高的 OCT 成像速度。与也使用面阵相机的并行 OCT 技术不同，该系统保留了传统的单模光纤点扫描机制，以提供共聚焦门，从而从样品中排除多次散射的光子。当使用 1000 Hz 共振扫描仪作为条纹扫描仪时，在 1 秒内获得了 1,016,000 个 A 扫描。通过以 1000 帧/秒的速度记录胚胎鸡心脏的体内 OCT 图像序列，验证了该方法的有效性。此外，还使用另一台高速相机获得了 2 兆赫兹的 OCT 数据。
