Hegoburu Chloé, Parrot Sandrine, Ferreira Guillaume, Mouly Anne-Marie
Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, University Lyon1, Lyon, France.
INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France.
Learn Mem. 2014 Nov 17;21(12):651-5. doi: 10.1101/lm.036558.114. Print 2014 Dec.
Although the basolateral amygdala (BLA) plays a crucial role for the acquisition of fear memories, sensory cortices are involved in their long-term storage in rats. However, the time course of their respective involvement has received little investigation. Here we assessed the role of the glutamatergic N-methyl-d-aspartate (NMDA) receptors in the BLA and olfactory cortex at discrete moments of an odor fear conditioning session. We showed that NMDA receptors in BLA are critically involved in odor fear acquisition during the first association but not during the next ones. In the cortex, NMDA receptor activation at encoding is not necessary for recent odor fear memory while its role in remote memory storage needs further investigation.
尽管基底外侧杏仁核（BLA）在恐惧记忆的获取中起着关键作用，但感觉皮层参与了大鼠恐惧记忆的长期存储。然而，它们各自参与的时间进程却很少受到研究。在此，我们在气味恐惧条件反射实验的不同时间点评估了BLA和嗅觉皮层中谷氨酸能N-甲基-D-天冬氨酸（NMDA）受体的作用。我们发现，BLA中的NMDA受体在首次关联期间对气味恐惧的获取至关重要，但在后续关联期间并非如此。在皮层中，编码时NMDA受体的激活对于近期气味恐惧记忆并非必要，而其在远期记忆存储中的作用尚需进一步研究。
