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携带小鼠乳腺肿瘤病毒ras融合基因的转基因小鼠：在不同组织中的不同效应。

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

作者信息

Tremblay P J, Pothier F, Hoang T, Tremblay G, Brownstein S, Liszauer A, Jolicoeur P

机构信息

Laboratory of Molecular Biology, Institut de Recherches Cliniques de Montréal, Quebec, Canada.

出版信息

Mol Cell Biol. 1989 Feb;9(2):854-9. doi: 10.1128/mcb.9.2.854-859.1989.

DOI:10.1128/mcb.9.2.854-859.1989
PMID:2540427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362668/
Abstract

Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.

摘要

制备了在小鼠乳腺肿瘤病毒长末端重复序列控制下携带v-Ha-ras癌基因的转基因小鼠。这些小鼠表现出几种表型：乳腺肿瘤、哈德氏泪腺双侧增生、原发性支气管肺泡肺腺癌和脾肿大。在乳腺、哈德氏腺和肺部肿瘤中检测到高水平的转基因RNA。在肿大的脾脏中发现了髓系细胞的积累。这种表型可能代表v-Ha-ras表达对髓系祖细胞的间接影响。我们的数据说明了v-Ha-ras的细胞特异性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b4/362668/afa2457f9d5d/molcellb00050-0510-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b4/362668/afa2457f9d5d/molcellb00050-0510-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b4/362668/afa2457f9d5d/molcellb00050-0510-a.jpg

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本文引用的文献

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Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas.基因产物改变与人类肺癌和结肠癌中细胞rasK基因的激活有关。
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Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.在转基因小鼠中，活化的小鼠Notch1和Notch3的过表达会阻碍乳腺发育并诱发乳腺肿瘤。
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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.T细胞受体低级别刺激后，Jurkat T细胞中的Ras激活对N-Ras具有特异性，且仅发生在高尔基体上。
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Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.携带并表达MTV/ myc融合基因的转基因小鼠中的自发性乳腺腺癌。
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Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells.显微注射人H-ras（T-24）蛋白的致癌基因形式会导致静止细胞快速增殖。
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Separation of hemopoietic cells from adult mouse marrow by use of monoclonal antibodies.利用单克隆抗体从成年小鼠骨髓中分离造血细胞。
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