Araki Syunsuke, Miki Atsushi, Yamashita Tsutomu, Goto Katsutoshi, Haruishi Kazuko, Ieki Yoshiaki, Kiryu Junichi
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan ; Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Japan.
Clin Ophthalmol. 2014 Nov 7;8:2199-207. doi: 10.2147/OPTH.S69501. eCollection 2014.
To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.
A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).
The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.
We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.
比较单眼弱视患者弱视眼和健眼的黄斑视网膜厚度及视神经乳头（ONH）参数特征。
共对21名单眼弱视患者（14例屈光参差性弱视患者、4例斜视性弱视患者以及3例兼具两种情况的患者）进行了频域光学相干断层扫描检查。患者的平均年龄为8.5±3.5岁。所检查的参数包括黄斑平均厚度（全层、内层和外层）、神经节细胞复合体厚度以及视盘周围视网膜神经纤维层（cpRNFL）厚度，还有ONH参数（边缘体积、视神经乳头体积、杯状体积、边缘面积、视盘面积、杯状面积以及杯盘面积比）。
弱视眼的远视程度显著高于健眼（P<0.001）。在黄斑视网膜厚度参数中，弱视眼的cpRNFL厚度（P<0.01）、黄斑全层视网膜厚度（3mm区域）（P<0.01）以及黄斑外层视网膜厚度（1mm和3mm区域）（P<0.05）均显著厚于健眼，而神经节细胞复合体厚度、黄斑全层视网膜厚度（1mm区域）以及黄斑内层视网膜厚度（1mm和3mm区域）差异不显著。在ONH参数中，弱视眼的边缘面积显著大于健眼，杯盘面积比小于健眼（P<0.05）。其他ONH参数在被研究的两眼之间均无显著差异。1mm区域的cpRNFL厚度和黄斑外层视网膜厚度差异与眼轴长度差异显著相关（分别为P<0.05，r=-0.48；P<0.01，r=-0.59）以及与屈光不正显著相关（分别为P<0.05，r=0.50；P<0.01，r=0.60）。其他参数与眼轴长度、屈光不正或最佳矫正视力差异均无显著相关性。
我们发现弱视眼和健眼在一些形态学测量上存在显著差异，这些差异似乎独立于视皮层异常。
