Liao Na, Jiang Huilv, Mao Guangyun, Li Yiyu, Xue Anquan, Lan Yuan, Lin Hao, Wang Qinmei
School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University Wenzhou, Zhejiang, China.
Am J Transl Res. 2019 Aug 15;11(8):5086-5095. eCollection 2019.
It is controversial that retina and photoreceptors are involved in amblyopic development. Lack of imaging devices for quantitative assessment of photoreceptors in vivo impedes further investigation. In this study we investigated the differences of macular thickness, outer nuclear layer (ONL) thickness and cone density among eyes with unilateral anisometropic amblyopia, amblyopic fellow eyes, and normal control eyes using high-definition spectral-domain optical coherence tomography and adaptive optics imaging system. Thicker fovea and parafovea with characteristic quantitative retinal changes in unilateral amblyopic patients indicated that the amblyopic process might involve the retina. Cones tended to be homogeneously distributed at 1.5° from the foveal center in all participants. However, we did not detect any significant differences in cone density and ONL thickness at 1.5° from the foveal center in patients with unilateral amblyopia when compared with the fellow eyes and the normal control eyes. This is the first study to explore whether photoreceptors are involved in amblyopic development in vivo that would help for understanding the underlying mechanisms of amblyopia. Whether macular changes relate to cone photoreceptors migration of the amblyopic eyes remains to be determined.
视网膜和光感受器是否参与弱视的发展存在争议。缺乏用于在体定量评估光感受器的成像设备阻碍了进一步的研究。在本研究中，我们使用高分辨率光谱域光学相干断层扫描和自适应光学成像系统，研究了单侧屈光参差性弱视眼、弱视对侧眼和正常对照眼之间黄斑厚度、外核层（ONL）厚度和视锥细胞密度的差异。单侧弱视患者中较厚的中央凹和旁中央凹以及特征性的定量视网膜变化表明，弱视过程可能涉及视网膜。在所有参与者中，视锥细胞倾向于在距中央凹中心1.5°处均匀分布。然而，与对侧眼和正常对照眼相比，我们未检测到单侧弱视患者在距中央凹中心1.5°处的视锥细胞密度和ONL厚度有任何显著差异。这是第一项在体探索光感受器是否参与弱视发展的研究，这将有助于理解弱视的潜在机制。黄斑变化是否与弱视眼的视锥光感受器迁移有关仍有待确定。
