Vafaeimanesh Jamshid, Parham Mahmoud, Seyyedmajidi Mohammadreza, Bagherzadeh Mohammad
Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran.
Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran.
ScientificWorldJournal. 2014;2014:391250. doi: 10.1155/2014/391250. Epub 2014 Oct 23.
Helicobacter pylori (HP) is a common worldwide infection with known gastrointestinal and nongastrointestinal complications. One of the gastrointestinal side effects posed for this organism is its role in diabetes and increased insulin resistance. The aim of this study was to evaluate the association between HP and insulin resistance in type 2 diabetic patients and nondiabetics. This cross-sectional study was carried out from May to December 2013 on 211 diabetic patients referred to diabetes clinic of Shahid Beheshti Hospital of Qom and 218 patients without diabetes. HP was evaluated using serology method and insulin resistance was calculated using HOMA-IR. The prevalence of H. pylori infection was 55.8% and 44.2% in diabetics and nondiabetics (P = 0.001). The study population was divided into two HP positive and negative groups. Among nondiabetics, insulin resistance degree was 3.01 ± 2.12 and 2.74 ± 2.18 in HP+ and HP- patients, respectively (P = 0.704). Oppositely, insulin resistance was significantly higher in diabetic HP+ patients rather than seronegative ones (4.484 ± 2.781 versus 3.160 ± 2.327, P = 0.013). In diabetic patients, in addition to higher prevalence of HP, it causes a higher degree of insulin resistance.
幽门螺杆菌（HP）是一种全球常见的感染菌，会引发已知的胃肠道及非胃肠道并发症。该病菌造成的一种胃肠道副作用是其在糖尿病及胰岛素抵抗增加方面所起的作用。本研究的目的是评估2型糖尿病患者和非糖尿病患者中幽门螺杆菌与胰岛素抵抗之间的关联。这项横断面研究于2013年5月至12月进行，研究对象为211名转诊至库姆市沙希德·贝赫什提医院糖尿病门诊的糖尿病患者以及218名非糖尿病患者。采用血清学方法评估幽门螺杆菌，使用稳态模型评估法（HOMA-IR）计算胰岛素抵抗。糖尿病患者和非糖尿病患者中幽门螺杆菌感染率分别为55.8%和44.2%（P = 0.001）。研究人群被分为幽门螺杆菌阳性和阴性两组。在非糖尿病患者中，幽门螺杆菌阳性和阴性患者的胰岛素抵抗程度分别为3.01±2.12和2.74±2.18（P = 0.704）。相反，糖尿病幽门螺杆菌阳性患者的胰岛素抵抗显著高于血清阴性患者（4.484±2.781对3.160±2.327，P = 0.013）。在糖尿病患者中，除了幽门螺杆菌感染率较高外，它还会导致更高程度的胰岛素抵抗。
