Talebi-Taher Mahshid, Mashayekhi Manizheh, Hashemi Mohammad Hossein, Bahrani Vanosheh
Department of Infectious Disease , Antimicrobial Resistance Research Center, Rasoul-e-Akram Hospital,Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2012;50(5):315-8.
Helicobacter pylori (H. pylori) is one of the most common chronic infections in patients with gastrointestinal disorders. Recent reports suggested that H. pylori might have high prevalence among patients with diabetes. The aim of this cross-sectional study was to assess the prevalence of H. pylori infection in diabetes mellitus and to study the relationship between histological findings and H. pylori infection in diabetic patients. Eighty patients with dyspepsia that were referred to our gastrointestinal department between May 2007 and May 2008 were included in our study. We checked fasting blood sugar for all of the study samples. All of patients underwent upper endoscopy and biopsy specimens were obtained from the antrum and the corpus. The specimens for the presence of H. pylori were colored by Giemsa stains. A single pathologist evaluated the histology slides. We found that prevalence of H. pylori infection was significantly higher in diabetics than in non-diabetics (P=0.001). Indeed, the prevalence of gastritis did differ significantly between the two groups (P=0.001). According to our results diabetes mellitus is one of the risk factor that must be considered in evaluation of H. pylori infection in diabetic patients with dyspepsia.
幽门螺杆菌（H. pylori）是胃肠道疾病患者中最常见的慢性感染之一。最近的报告表明，幽门螺杆菌在糖尿病患者中的患病率可能较高。这项横断面研究的目的是评估糖尿病患者中幽门螺杆菌感染的患病率，并研究糖尿病患者组织学检查结果与幽门螺杆菌感染之间的关系。2007年5月至2008年5月间转诊至我院胃肠科的80例消化不良患者纳入本研究。我们对所有研究样本进行空腹血糖检查。所有患者均接受上消化道内镜检查，并从胃窦和胃体获取活检标本。用吉姆萨染色法检测幽门螺杆菌的存在。由一名病理学家评估组织学切片。我们发现，糖尿病患者中幽门螺杆菌感染的患病率显著高于非糖尿病患者（P = 0.001）。事实上，两组之间胃炎的患病率确实存在显著差异（P = 0.001）。根据我们的结果，糖尿病是评估消化不良糖尿病患者幽门螺杆菌感染时必须考虑的危险因素之一。
