Vafaeimanesh Jamshid, Heidari Akram, Effatpanah Marzieh, Parham Mahmoud
Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Research Center for Medicine and Religion, Qom University of Medical Sciences, Qom, Iran.
ScientificWorldJournal. 2014 Jan 9;2014:402685. doi: 10.1155/2014/402685. eCollection 2014.
Increased insulin resistance is an extragastrointestinal manifestation of Helicobacter pylori (HP) infection. HP changes the level of inflammatory markers and cytokines and changes the adipocyte function by altering the adiponectin level. Given the high prevalence of HP and diabetes in our society, we evaluated the association between HP and serum adiponectin level. In this cross-sectional study, 211 diabetic patients under treatment other than insulin were studied. These patients were divided into two groups of HP+ and HP- based on their HP IgG antibody serology and their blood adiponectin levels were measured. Data was analyzed using independent t-test, Chi-square test, and Fisher's exact test.
Seventy-two patients with an average age of 51.56 ± 8.34 years were HP- and 139 patients with an average age of 50.35 ± 9.01 years were HP+. The mean serum adiponectin level in HP- and HP+ groups was 4.54 ± 5.43 and 5.64 ± 3.88 ng/mL, respectively. Insulin resistance degree was significantly higher in HP+ group (HP- = 3.160 ± 3.327 versus HP+ = 4.484 ± 3.781, P = 0.013) but no significant difference was found between the mean serum adiponectin level in HP- and HP+ groups (P = 0.140).
Although the insulin resistance degree was significantly higher in HP+ diabetic patients, no significant relationship was found between HP infection and serum levels of adiponectin.
胰岛素抵抗增加是幽门螺杆菌（HP）感染的一种胃肠道外表现。HP通过改变脂联素水平来改变炎症标志物和细胞因子的水平，并改变脂肪细胞功能。鉴于我国社会中HP和糖尿病的高患病率，我们评估了HP与血清脂联素水平之间的关联。在这项横断面研究中，对211名接受非胰岛素治疗的糖尿病患者进行了研究。根据他们的HP IgG抗体血清学将这些患者分为HP阳性和HP阴性两组，并测量他们的血液脂联素水平。使用独立样本t检验、卡方检验和Fisher精确检验对数据进行分析。
72名平均年龄为51.56±8.34岁的患者为HP阴性，139名平均年龄为50.35±9.01岁的患者为HP阳性。HP阴性和HP阳性组的平均血清脂联素水平分别为4.54±5.43和5.64±3.88 ng/mL。HP阳性组的胰岛素抵抗程度显著更高（HP阴性=3.160±3.327，HP阳性=4.484±3.781，P=0.013），但HP阴性和HP阳性组的平均血清脂联素水平之间未发现显著差异（P=0.140）。
虽然HP阳性糖尿病患者的胰岛素抵抗程度显著更高，但未发现HP感染与血清脂联素水平之间存在显著关系。
