Kownatzki E, Neumann M, Uhrich S
Abteilung für Experimentelle Dermatologie, Universitäts-Hautklinik, Freiburg, FRG.
Agents Actions. 1989 Jan;26(1-2):180-2. doi: 10.1007/BF02126601.
Human monocytes upon stimulation with bacterial lipopolysaccharide release two cytokines which modulate the functions of neutrophilic granulocytes (PMN), a monocyte-derived chemotaxin (MOC) and tumor necrosis factor (TNF). Both cytokines stimulated the adherence of PMN on protein-coated nylon-fibers. Whereas MOC is one of the four most potent chemoattractants known, TNF was a most powerful inhibitor of PMN chemotactic migration towards several chemotactic factors including MOC. Neither cytokine stimulated the release of superoxide anion (O2-) or hydrogen peroxide (H2O2) from PMN in suspension. However, TNF, but not MOC, caused the release of considerable amounts of H2O2 and O2- from PMN attached to nylon fibers. The two cytokines have similar effects on the adherence, opposing effects on chemotactic migration and different effects on the oxidative burst of PMN.
人类单核细胞在受到细菌脂多糖刺激后会释放两种细胞因子，它们可调节嗜中性粒细胞（PMN）的功能，一种是单核细胞衍生趋化因子（MOC），另一种是肿瘤坏死因子（TNF）。这两种细胞因子都能刺激PMN黏附于蛋白包被的尼龙纤维上。虽然MOC是已知的四种最有效的趋化剂之一，但TNF却是PMN向包括MOC在内的多种趋化因子进行趋化迁移的最有力抑制剂。这两种细胞因子都不会刺激悬浮状态下的PMN释放超氧阴离子（O2-）或过氧化氢（H2O2）。然而，TNF而非MOC会使附着于尼龙纤维上的PMN释放大量的H2O2和O2-。这两种细胞因子对PMN的黏附作用相似，对趋化迁移作用相反，对PMN氧化爆发的作用也不同。
