Carmichael J A, Maskens P D
Department of Obstetrics and Gynaecology, Queen's University Medical School, Kingston, Ontario, Canada.
Am J Obstet Gynecol. 1989 Apr;160(4):916-8. doi: 10.1016/0002-9378(89)90310-4.
Evidence suggests a link between human papillomavirus infections and cervical dysplasia-carcinoma. This has led to the recommendation that when human papillomavirus infections are identified on the cervix, especially in association with dysplasia, these patients should have colposcopic assessment and treatment. The natural history of cervical human papillomavirus infections, particularly when associated with mild or moderate dysplasia, is not clear. To assess this question, 235 women with mild to moderate cervical dysplasia associated with a human papillomavirus infection were prospectively evaluated at 6-month intervals by the Colposcopy Clinic. This review suggests that mild to moderate cervical dysplasia associated with human papillomavirus infection eventually spontaneously disappears or, at worse, lingers on over many months in a mild to moderate form. These observations do not support the current popular practice of treating all mild to moderate cervical dysplasias associated with human papillomavirus infection or cervical human papillomavirus infection not associated with dysplastic lesions.
有证据表明人乳头瘤病毒感染与宫颈发育异常-癌之间存在联系。这导致了一项建议，即当在宫颈上发现人乳头瘤病毒感染时，尤其是与发育异常相关时，这些患者应接受阴道镜评估和治疗。宫颈人乳头瘤病毒感染的自然史，特别是与轻度或中度发育异常相关时，尚不清楚。为评估这个问题，阴道镜诊所对235名伴有人乳头瘤病毒感染的轻度至中度宫颈发育异常的女性进行了前瞻性评估，每隔6个月进行一次检查。该综述表明，与人乳头瘤病毒感染相关的轻度至中度宫颈发育异常最终会自发消失，或者在最坏的情况下，会以轻度至中度的形式持续数月。这些观察结果不支持目前普遍存在的治疗所有与人乳头瘤病毒感染相关的轻度至中度宫颈发育异常或与发育异常病变无关的宫颈人乳头瘤病毒感染的做法。
