青霉二烯A和B，从海洋分离的双孢青霉MA-267中得到的具有三环[6.3.1.0(1,5)]十二烷骨架的倍半萜。

Penicibilaenes A and B, sesquiterpenes with a tricyclo[6.3.1.0(1,5)]dodecane skeleton from the marine isolate of Penicillium bilaiae MA-267.

作者信息

Meng Ling-Hong, Li Xiao-Ming, Liu Yang, Wang Bin-Gui

机构信息

†Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.

‡University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, People's Republic of China.

出版信息

Org Lett. 2014 Dec 5;16(23):6052-5. doi: 10.1021/ol503046u. Epub 2014 Nov 19.

DOI:10.1021/ol503046u

PMID:25408229

Abstract

Penicibilaenes A (1) and B (2), two sesquiterpenes possessing a tricyclo[6.3.1.0(1,5)]dodecane skeleton, were characterized from Penicillium bilaiae MA-267, a fungus obtained from the rhizospheric soil of the mangrove plant Lumnitzera racemosa. The lack of some key COSY and NOESY correlations made the structure elucidation of compound 1 difficult, which was solved by a X-ray crystallographic study. Compounds 1 and 2 exhibited selective activity against the plant pathogenic fungus Colletotrichum gloeosporioides (MIC = 1.0 and 0.125 μg/mL, respectively).

摘要

从红树植物总状卤蕨根际土壤中分离得到的真菌比莱青霉MA-267中鉴定出了青霉倍半萜烯A（1）和B（2），这两种倍半萜具有三环[6.3.1.0(1,5)]十二烷骨架。由于缺少一些关键的COSY和NOESY相关信息，化合物1的结构解析存在困难，通过X射线晶体学研究得以解决。化合物1和2对植物病原真菌胶孢炭疽菌表现出选择性活性（MIC分别为1.0和0.125 μg/mL）。