青霉素吡喃酮 A 和 B，一种海洋来源的青霉属真菌产生的混合倍半萜。

Penicillipyrones A and B, meroterpenoids from a marine-derived Penicillium sp. fungus.

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

出版信息

J Nat Prod. 2014 Feb 28;77(2):406-10. doi: 10.1021/np400826p. Epub 2014 Jan 17.

DOI:10.1021/np400826p

PMID:24437979

Abstract

Penicillipyrones A (1) and B (2), two novel meroterpenoids, were isolated from the marine-derived fungus Penicillium sp. On the basis of the results of combined spectroscopic analyses, these compounds were structurally elucidated to be sesquiterpene γ-pyrones from a new skeletal class derived from a unique linkage pattern between the drimane sesquiterpene and pyrone moieties. Compound 2 elicited significant induction of quinone reductase.

摘要

Penicillipyrones A (1) 和 B (2)，两种新型的杂合倍半萜，从海洋来源的真菌青霉属 (Penicillium sp.) 中分离得到。基于综合光谱分析的结果，这些化合物的结构被阐明为来自独特连接模式的倍半萜 γ-吡喃酮，该模式在倍半萜和吡喃酮部分之间。化合物 2 引起了醌还原酶的显著诱导。