General Safety Section, General Services Department, Birzeit University, Ramallah 00972, Palestine.
Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Ramallah 00972, Palestine.
Toxins (Basel). 2023 Jan 18;15(2):93. doi: 10.3390/toxins15020093.
To combat the ineffectiveness of currently available pharmaceutical medications, caused by the emergence of increasingly resistant bacterial and fungal strains, novel antibacterial and antifungal medications are urgently needed. Novel natural compounds with antimicrobial activities can be obtained by exploring underexplored habitats such as the world's oceans. The oceans represent the largest ecosystem on earth, with a high diversity of organisms. Oceans have received some attention in the past few years, and promising compounds with antimicrobial activities were isolated from marine organisms such as bacteria, fungi, algae, sea cucumbers, sea sponges, etc. This review covers 56 antifungal and 40 antibacterial compounds from marine organisms. These compounds are categorized according to their chemical structure groups, including polyketides, alkaloids, ribosomal peptides, and terpenes, and their organismal origin. The review provides the minimum inhibitory concentration MIC values and the bacterial/fungal strains against which these chemical compounds show activity. This study shows strong potential for witnessing the development of new novel antimicrobial drugs from these natural compounds isolated and evaluated for their antimicrobial activities.
为了应对当前药物治疗的无效性，这些药物由于细菌和真菌耐药性的不断出现而失效，因此迫切需要新型的抗菌和抗真菌药物。通过探索世界海洋等未充分开发的栖息地，可以获得具有抗菌活性的新型天然化合物。海洋是地球上最大的生态系统，拥有丰富多样的生物。过去几年中，海洋受到了一定的关注，并且已经从海洋生物（如细菌、真菌、藻类、海参、海海绵等）中分离出具有抗菌活性的有前途的化合物。这篇综述涵盖了 56 种抗真菌化合物和 40 种抗菌化合物，这些化合物根据其化学结构类型（包括聚酮类、生物碱、核糖体肽和萜类化合物）和生物起源进行分类。综述提供了最低抑菌浓度（MIC）值以及这些化学化合物对其具有活性的细菌/真菌菌株。这项研究表明，从这些天然化合物中分离并评估其抗菌活性，具有开发新型新型抗菌药物的巨大潜力。
