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脂联素基因多态性与结直肠癌风险增加相关。

Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer.

作者信息

Yang Xiaoyu, Li Jinsong, Cai Weimei, Yang Qinghui, Lu Zhihong, Yu Jian, Yu Hong, Zhang Na, Sun Deyu, Qu Yanli, Guo Hong, Wen Fengyun, Ji Yinghua

机构信息

Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Xinxiang, China (mainland).

Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Xinxiang, China (mainland).

出版信息

Med Sci Monit. 2015 Sep 2;21:2595-606. doi: 10.12659/MSM.893472.

DOI:10.12659/MSM.893472
PMID:26329379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4562615/
Abstract

BACKGROUND

This meta-analysis investigates the associations of adiponectin (ADIPOQ) genetic polymorphisms with the susceptibility to colorectal cancer (CRC).

MATERIAL AND METHODS

2 reviewers independently searched 6 databases - PubMed, Cochrane Library, Ovid, Embase, China National Knowledge Infrastructure (CNKI) and Wanfang databases - to identify published studies relevant to adiponectin gene polymorphisms and CRC. Studies retrieved from database searches were screened using our stringent inclusion and exclusion criteria. Full texts of the selected studies were accessed and related data was extracted using a standardized data extraction form. Comprehensive Meta-analysis 2.0 software was used for statistical analyses.

RESULTS

A total of 188 studies were initially retrieved from database search, and 6 studies were eventually selected, through a rigorous screening process, for inclusion in this meta-analysis. The 6 studies contained a total of 1897 patients (Asians: 1190; white: 707) with CRC in case group and 2475 healthy controls (Asians: 1325; white: 1150) in the control group. Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with increased risk of CRC; and rs266729 C>G SNP under allele model conferred an increased risk of CRC.

CONCLUSIONS

Our meta-analysis strongly suggests that the ADIPOQ rs2241766 T>G, rs1501299 G>T, and rs266729 C>G SNPs correlate with an increased risk of CRC.

摘要

背景

本荟萃分析旨在研究脂联素（ADIPOQ）基因多态性与结直肠癌（CRC）易感性之间的关联。

材料与方法

两名研究者独立检索了6个数据库——PubMed、Cochrane图书馆、Ovid、Embase、中国知网（CNKI）和万方数据库——以确定与脂联素基因多态性和CRC相关的已发表研究。使用我们严格的纳入和排除标准对从数据库检索中获得的研究进行筛选。获取所选研究的全文，并使用标准化的数据提取表提取相关数据。使用综合Meta分析2.0软件进行统计分析。

结果

通过数据库检索最初共检索到188项研究，经过严格筛选过程，最终选择6项研究纳入本荟萃分析。这6项研究的病例组共有1897例CRC患者（亚洲人：1190例；白人：707例），对照组有2475例健康对照（亚洲人：1325例；白人：1150例）。当前荟萃分析的结果显示，rs2241766 T>G单核苷酸多态性（SNP）会增加患CRC的风险；显性模型下的rs1501299 G>T与CRC风险增加相关；等位基因模型下的rs266729 C>G SNP会增加患CRC的风险。

结论

我们的荟萃分析有力地表明，ADIPOQ的rs2241766 T>G、rs1501299 G>T和rs266729 C>G SNPs与CRC风险增加相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2240/4562615/870d7cc2073f/medscimonit-21-2595-g009.jpg
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