Cojocaru Gabriel R, Popa-Wagner Aurel, Stanciulescu Elena C, Babadan Loredana, Buga Ana-Maria
Department of Functional Sciences, Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares str., no 2, Craiova, 200349 Romania.
Department of Psychiatry, University of Medicine Rostock, Rostock, Germany.
J Mol Psychiatry. 2013 Aug 23;1(1):14. doi: 10.1186/2049-9256-1-14. eCollection 2013.
Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system affect both directly and indirectly the function in a variety of organs, including the brain, with consequent neurological (motor and sensory performance) and cognitive impairments, as well as leading to the development of various psychiatric diseases. Post-stroke depression (PSD) is among the most frequent neuropsychiatric consequences of cerebral ischemia. This review discusses several animal models used for the study of PSD and summarizes recent findings in the genomic profile of the ageing brain, which are associated with age-related disorders in the elderly. Since stroke and depression are diseases with increased incidence in the elderly, great clinical benefit may especially accrue from deciphering and targeting basic mechanisms underlying PSD. Finally, we discuss the relationship between ageing, circadian rhythmicity and PSD.
衰老与各种器官系统功能的变化相关。心血管系统的变化直接或间接地影响包括大脑在内的多种器官的功能，从而导致神经学（运动和感觉功能）和认知障碍，以及引发各种精神疾病。中风后抑郁症（PSD）是脑缺血最常见的神经精神后果之一。本综述讨论了用于研究PSD的几种动物模型，并总结了衰老大脑基因组图谱的最新发现，这些发现与老年人的年龄相关疾病有关。由于中风和抑郁症在老年人中的发病率增加，因此从解读和靶向PSD潜在的基本机制中可能会获得巨大的临床益处。最后，我们讨论衰老、昼夜节律和PSD之间的关系。
