Yefet Enav, Salim Raed, Chazan Bibiana, Akel Hiba, Romano Shabtai, Nachum Zohar
Department of Obstetrics & Gynecology, Emek Medical Center, Afula, Israel.
Labor and Delivery Unit, Obstetrics & Gynecology, Emek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Obstet Gynecol Surv. 2014 Nov;69(11):681-94. doi: 10.1097/OGX.0000000000000122.
Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy. This review aimed to explore the mechanisms of action of the quinolones and fluoroquinolones, which set the stage for concerns regarding possible teratogenic and mutagenic effects; to clarify the clinical dilemmas that brought forth the necessity in reevaluating the use of those medications during pregnancy; and to review the accumulated data regarding their safety during pregnancy in animal models and humans.
喹诺酮类和氟喹诺酮类是高效抗生素。然而，对其可能有害影响的担忧限制了它们在孕期的使用。尽管如此，越来越多的临床数据表明它们在孕期可能是安全的。本综述旨在探讨喹诺酮类和氟喹诺酮类的作用机制，这些机制引发了对其可能致畸和致突变作用的担忧；阐明重新评估这些药物在孕期使用必要性的临床困境；并回顾在动物模型和人类中关于它们孕期安全性的累积数据。
