Messenger Ali M, Barr Kelli L, Weppelmann Thomas A, Barnes Amber N, Anderson Benjamin D, Okech Bernard A, Focks Dana A
Department of Environmental and Global Health, College of Public Health and Health Profession, and Emerging Pathogens Institute, University of Florida , Gainesville, Florida.
Vector Borne Zoonotic Dis. 2014 Nov;14(11):783-7. doi: 10.1089/vbz.2014.1665.
Dengue fever is the most important mosquito-borne viral disease in the world, with 40% of the global population at risk of infection. Dengue virus is responsible for infections in over 100 countries, including the Americas and Caribbean Basin; however, it has been largely eradicated from the United States through the implementation of effective vector control programs. However, between 2009 and 2010, 27 permanent residents of Key West, Florida, were reported to have locally acquired infections, marking the first autochthonous cases detected in Florida since 1934. Despite this recent and unusual transmission, and the potential risk of serious illness associated with sequential infections, no active surveillance had been conducted since.
A serosurvey of permanent residents of Key West, Florida, was conducted in March of 2012. After informed consent, enrolled participants (n=173) were given a dengue virus rapid diagnostic test and completed a corresponding questionnaire.
The presence of immunoglobulin G (IgG) antibodies was indicated in 12 participants (6.9%), all of whom reported travel to endemic countries within the past 2 years. Surprisingly, six participants (3.5%) without any recent travel outside the state of Florida gave positive results for IgM antibodies. The presence of birdbaths and bromeliads on the property and sleeping outdoors emerged as significant factors related to previous exposure, whereas home air conditioning without the use of open windows and the use of mosquito repellent were protective.
These findings suggest local transmission occurred in Key West in early 2012, indicating that transmission may not have subsided in 2010.
登革热是世界上最重要的蚊媒病毒病，全球40%的人口有感染风险。登革病毒在包括美洲和加勒比海盆地在内的100多个国家引发感染；然而，通过实施有效的病媒控制计划，美国已基本消灭了登革热。不过，在2009年至2010年期间，据报告佛罗里达州基韦斯特的27名常住居民发生了本地感染，这是自1934年以来在佛罗里达州首次检测到的本土病例。尽管近期出现了这种不寻常的传播情况，以及与连续感染相关的严重疾病潜在风险，但此后一直没有进行主动监测。
2012年3月对佛罗里达州基韦斯特的常住居民进行了血清学调查。在获得知情同意后，对纳入的参与者（n = 173）进行了登革病毒快速诊断检测，并填写了相应问卷。
12名参与者（6.9%）检测出存在免疫球蛋白G（IgG）抗体，他们均报告在过去2年内前往过流行国家。令人惊讶的是，6名近期没有出过佛罗里达州的参与者（3.5%）IgM抗体检测呈阳性。房产内有露天水缸和凤梨科植物以及户外睡眠是与既往接触相关的重要因素，而家中使用空调且不开窗户以及使用驱蚊剂则具有保护作用。
这些发现表明2012年初基韦斯特发生了本地传播，这表明传播可能在2010年并未平息。
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