MMWR Morb Mortal Wkly Rep. 2010 May 21;59(19):577-81.
Dengue is the most common vector-borne viral disease in the world, causing an estimated 50-100 million infections and 25,000 deaths each year. During 1946-1980, no cases of dengue acquired in the continental United States were reported. Since 1980, a few locally acquired U.S. cases have been confirmed along the Texas-Mexico border, temporally associated with large outbreaks in neighboring Mexican cities. On September 1, 2009, a New York physician notified the Monroe County (Florida) Health Department (MCHD) and the Florida Department of Health (FDOH) of a suspected dengue case in a New York state resident whose only recent travel was to Key West, Florida. CDC confirmed the diagnosis, and a press release was issued to notify the public and Key West physicians of the potential risk for locally acquired dengue infections. In the next 2 weeks, two dengue infections in Key West residents without recent travel were reported and confirmed. Subsequently, enhanced and active surveillance identified 24 more Key West cases during 2009. On April 13, 2010, another Key West dengue case was reported to FDOH, bringing the total to 28. This report describes the first three dengue cases reported in 2009, briefly summarizes the 2010 case, highlights preliminary findings from the ongoing investigation, and outlines measures used to mitigate and control the outbreak. Clinicians should include dengue in the differential diagnosis of acute febrile illnesses in patients who live in or have recently traveled to subtropical areas of the United States or to the tropics.
登革热是全球最常见的虫媒病毒病，每年估计有 5000 万至 1 亿例感染和 25000 人死亡。1946 年至 1980 年期间，美国大陆没有报告登革热本地感染病例。自 1980 年以来，在美国德克萨斯州与墨西哥边境地区确认了几例美国本地获得的登革热病例，这些病例与邻近墨西哥城市的大型疫情有关。2009 年 9 月 1 日，一位纽约医生向门罗县（佛罗里达州）卫生局（MCHD）和佛罗里达州卫生部（FDOH）报告了一名纽约居民的疑似登革热病例，该居民最近的旅行仅到佛罗里达州的基韦斯特。CDC 确认了诊断，并发布了一份新闻稿，通知公众和基韦斯特医生存在本地获得登革热感染的潜在风险。在接下来的 2 周内，报告并确认了两名没有近期旅行的基韦斯特居民的登革热感染病例。随后，加强和积极的监测在 2009 年期间又发现了 24 例基韦斯特病例。2010 年 4 月 13 日，向 FDOH 报告了另一起基韦斯特登革热病例，使总数达到 28 例。本报告描述了 2009 年报告的前 3 例登革热病例，简要总结了 2010 年病例，突出了正在进行的调查的初步结果，并概述了用于减轻和控制疫情的措施。临床医生应将登革热纳入居住在美国亚热带地区或热带地区或最近旅行到这些地区的急性发热性疾病的鉴别诊断中。
