Bürki F, Nowotny N, Rossmanith W, Pallan C, Möstl K
Dtsch Tierarztl Wochenschr. 1989 Apr;96(4):162-5.
During 3 foaling seasons around 150 Lipizzaner foals were vaccinated against ERP with commercial vaccines and groups thereof were serotested in CF and SN for their humoral immune response. In addition, 6 horses of cheaper common breeds were vaccinated on the University premises, were continuously serologically screened and subjected to virulent nasal test infection. The live-virus vaccine Prevaccinol interfered so profoundly and up to the 20th week of life with maternal antibodies that its further use was discontinued. The inactivated vaccine Pneumabort-K proved to be of impressive immunogenicity, but without any doubt must be used 4 times instead of 3 times only during the first year of life as recommended by its manufacturer. Proofs that the vaccination intervals as recommended on the packing slips are too far-spaced and that 3 basic doses of vaccine induce unsatisfactory protection became apparent under two aspects. Firstly, yearling mares experienced an enzootic field infection by subtype 1 of EHV 1 while on summer pasture. Secondly, experimental nasal infection of horses of the University herd gave takes certified clinically, virologically, and serologically. Data as well as arguments are brought forward which shed doubt on the merits of CF-titers as indicators of immunity as recommended by other authors; SN-titers were shown to be more dependable parameters. With regard to the frequently needed revaccinations there is an absolute "must" for the producer of Pneumabort-K to purify this product before marketing it.
在3个产驹季节里，约150匹利皮扎马驹用商业疫苗接种预防马脑脊髓炎，并对其中的几组进行补体结合试验（CF）和中和试验（SN）血清检测，以了解其体液免疫反应。此外，6匹普通廉价品种的马在大学校园内接种疫苗，持续进行血清学筛查，并接受强毒鼻内试验感染。活病毒疫苗Prevaccinol对母源抗体的干扰非常严重，直至驹马出生后20周，因此停止了该疫苗的进一步使用。灭活疫苗Pneumabort-K被证明具有令人印象深刻的免疫原性，但毫无疑问，必须按照其制造商的建议，在驹马出生后的第一年使用4次而不是3次。包装标签上推荐的疫苗接种间隔时间过长，3剂基础疫苗诱导的保护效果不理想，这一点从两个方面得到了证实。第一，一岁母马在夏季牧场时感染了1型马疱疹病毒的地方流行毒株。第二，对大学马群的马匹进行的试验性鼻内感染在临床、病毒学和血清学上均得到了确诊。文中提出了数据和论据，对其他作者推荐的以补体结合试验效价作为免疫指标的优点提出了质疑；结果表明，中和试验效价是更可靠的参数。关于频繁需要的再次接种，Pneumabort-K的生产商在销售该产品之前绝对“必须”对其进行提纯。
