Zhao Yi, Huang Leaf
Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Adv Genet. 2014;88:13-36. doi: 10.1016/B978-0-12-800148-6.00002-X.
Nonviral vectors which offer a safer and versatile alternative to viral vectors have been developed to overcome problems caused by viral carriers. However, their transfection efficacy or level of expression is substantially lower than viral vectors. Among various nonviral gene vectors, lipid nanoparticles are an ideal platform for the incorporation of safety and efficacy into a single delivery system. In this chapter, we highlight current lipidic vectors that have been developed for gene therapy of tumors and other diseases. The pharmacokinetic, toxic behaviors and clinic trials of some successful lipids particles are also presented.
为克服病毒载体所带来的问题，已开发出比病毒载体更安全、用途更广泛的非病毒载体。然而，它们的转染效率或表达水平远低于病毒载体。在各种非病毒基因载体中，脂质纳米颗粒是将安全性和有效性整合到单一递送系统中的理想平台。在本章中，我们重点介绍了目前已开发用于肿瘤和其他疾病基因治疗的脂质载体。还介绍了一些成功的脂质颗粒的药代动力学、毒性行为和临床试验情况。
