Richardson Mary S, Muller Susan
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Ave, EH 303D4, Charleston, SC, 29425, USA,
Head Neck Pathol. 2014 Dec;8(4):411-20. doi: 10.1007/s12105-014-0584-y. Epub 2014 Nov 20.
This is an update on selected odontogenic malignancies. The article deals with aspects of recognized odontogenic carcinomas, odontogenic sarcoma and a yet unrecognized entity, sclerosing odontogenic carcinoma. Odontogenic malignancies are exceedingly rare, complicating a thorough understanding of the biologic behavior, reproducible standardized diagnostic criteria, appropriate classification and clinical management. Without the knowledge of the tumor's biologic behavior, adequate clinical management is difficult and patient outcomes uncertain. The histopathologic features are emphasized as well as the more recent biomarker findings. These recent advances may facilitate further understanding of this group of malignancies and provide useful stratification to guide patient management.
本文是关于特定牙源性恶性肿瘤的最新进展。文章探讨了公认的牙源性癌、牙源性肉瘤以及一种尚未被充分认识的实体——硬化性牙源性癌的相关方面。牙源性恶性肿瘤极为罕见,这使得全面了解其生物学行为、可重复的标准化诊断标准、恰当的分类及临床管理变得复杂。若不了解肿瘤的生物学行为,就难以进行充分的临床管理,患者的预后也难以确定。文中强调了组织病理学特征以及最新的生物标志物研究结果。这些最新进展可能有助于进一步理解这组恶性肿瘤,并为指导患者管理提供有用的分层依据。