Del Corso G, Tardio M L, Gissi D B, Marchetti C, Montebugnoli L, Tarsitano A
Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, via S Vitale 59, Bologna, Italy,
Oral Maxillofac Surg. 2015 Mar;19(1):85-9. doi: 10.1007/s10006-014-0465-2. Epub 2014 Sep 14.
Ghost cell odontogenic carcinomas are rare neoplasms that arise in the maxillary bones either from a calcifying odontogenic cyst or de novo. They are aggressive locally and can metastasize. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a Caucasian male 86 years of age. We have described the clinical and radiographic features, histological characteristics, immunohistochemistry findings, and surgical treatment. We especially focused on how Ki-67 expression guides the treatment choice. Finally, we reviewed 32 cases described in the literature and compared them with the cases described up until 2014 to help clinicians identify the diagnostic characteristics of and select appropriate treatment modalities for ghost cell odontogenic carcinomas.
牙源性影细胞癌是一种罕见的肿瘤，发生于上颌骨，可源自钙化牙源性囊肿或原发。它们局部侵袭性强且可发生转移。我们在此报告一例发生于一名86岁白种男性下颌骨的牙源性影细胞癌病例。我们描述了其临床和影像学特征、组织学特点、免疫组化结果及手术治疗情况。我们特别关注Ki-67表达如何指导治疗选择。最后，我们回顾了文献中描述的32例病例，并将它们与截至2014年描述的病例进行比较，以帮助临床医生识别牙源性影细胞癌的诊断特征并选择合适的治疗方式。
