Takeuti Tharsus Dias, Terra Guilherme Azevedo, da Silva Alex Augusto, Terra Júverson Alves, da Silva Luci Mara, Crema Eduardo
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Arq Bras Cir Dig. 2014;27 Suppl 1(Suppl 1):51-5. doi: 10.1590/s0102-6720201400s100013.
Incretins are hormones produced by the intestine and can stimulate the secretion of insulin, helping to diminish the post-prandial glycemia. The administration of an emulsion of palm oil can help in the maintenance of the weight, and can increase circulating incretins levels. Glutamine increases the concentration of incretins in diabetic people. Both can help in metabolic syndrome.
To analyze the effects of ingestion of palm oil and glutamine in glycemia and in incretins in patients with diabetes submitted to surgical duodenojejunal exclusion with ileal interposition without gastrectomy.
Eleven diabetic type 2 patients were included and were operated. They were called to laboratory follow-up without eating anything between eight and 12 hours. They had there blood collected after the stimulus of the palm oil and glutamine taken in different days. For the hormonal doses were used ELISA kits.
The glycemia showed a meaningful fall between the fast and two hours after the stimulus of the palm oil (p=0,018). With the glutamine the GLP-1 showed an increase between the fast and one hour (p=0,32), the PYY showed an important increase between the fast and one hour after the stimulus (p=0,06), the glycemia showed a meaningful fall after two hours of the administration of the stimulus (p=0,03).
Palm oil and glutamine can influence intestinal peptides and glucose.
肠促胰岛素是由肠道产生的激素，可刺激胰岛素分泌，有助于降低餐后血糖。给予棕榈油乳剂有助于维持体重，并可提高循环中的肠促胰岛素水平。谷氨酰胺可增加糖尿病患者体内肠促胰岛素的浓度。两者都有助于改善代谢综合征。
分析摄入棕榈油和谷氨酰胺对接受非胃切除十二指肠空肠转位加回肠间置术的糖尿病患者血糖和肠促胰岛素的影响。
纳入11例2型糖尿病患者并进行手术。要求他们在8至12小时内禁食后到实验室进行随访。在不同日期摄入棕榈油和谷氨酰胺刺激后采集他们的血液。激素剂量检测使用酶联免疫吸附测定试剂盒。
血糖在禁食状态和棕榈油刺激后两小时之间有显著下降（p = 0.018）。使用谷氨酰胺时，胰高血糖素样肽-1（GLP-1）在禁食状态和一小时之间有所增加（p = 0.32），酪酪肽（PYY）在刺激后禁食状态和一小时之间有显著增加（p = 0.06），血糖在给予刺激两小时后有显著下降（p = 0.03）。
棕榈油和谷氨酰胺可影响肠道肽和葡萄糖。
