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报告:杜仲木材提取物抗菌活性的分子基础。

Report: Molecular basis of antibacterial activities in extracts of Eucommia ulmoides wood.

作者信息

Peng Wanxi, Ge Shengbo, Li Dongli, Mo Bo, Daochun Qin, Ohkoshi Makoto

机构信息

School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, China / Laboratory of Biomaterials Science, Kyoto Prefectural University, Kyoto, Japan.

School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, China.

出版信息

Pak J Pharm Sci. 2014 Nov;27(6 Suppl):2133-8.

PMID:25410085
Abstract

As one of the famous medicinal plants in China, the bark of Eucommia ulmoides is considered as the important traditional Chinese medicine. However, the constituents of Eucommia ulmoides wood isn't used effectively. Therefore, the molecules of wood extracts in Eucommia ulmoides are studied to further utilize the resources. The results show that the optimal extraction time period of ethanol/methanol extraction, petroleum ether/acetic ether extraction, and benzene/alcohol extraction are 3h, 5h, and 4h, respectively. Among sequential extractions, PABEEM extraction is the optimum extraction mode for the LRs is 22.95%. Its wood extracts included hexanedioic acid, bis(2-ethylhexyl) ester, 3,3,7,11-tetramethyltricyclo [5.4.0.0 (4,11)] undecan-1-ol, (all-E)- 2,6,10,15,19,23-hexamethyl- 2,6,10,14,18,22-tetracosahexaene, other rare drug and biomedical activities. And the wood extracts of Eucommia ulmoides is fit to extract 1,5-hexadien-3-yne, (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene.

摘要

杜仲作为中国著名的药用植物之一,其树皮被视为重要的传统中药。然而,杜仲木材的成分未得到有效利用。因此,对杜仲木材提取物的分子进行研究以进一步利用这些资源。结果表明,乙醇/甲醇提取、石油醚/乙酸乙酯提取和苯/乙醇提取的最佳提取时间段分别为3小时、5小时和4小时。在连续提取中,PABEEM提取是提取率为22.95%的LRs的最佳提取方式。其木材提取物包括己二酸双(2-乙基己基)酯、3,3,7,11-四甲基三环[5.4.0.0(4,11)]十一烷-1-醇、(全-E)-2,6,10,15,19,23-六甲基-2,6,10,14,18,22-二十四碳六烯、其他稀有药物和生物医学活性成分。杜仲木材提取物适合提取1,5-己二烯-3-炔、(全-E)-2,6,10,15,19,23-六甲基-2,6,10,14,18,22-二十四碳六烯。

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