血清维生素B-12和叶酸浓度较低，硫胺素和核黄素摄入量较低，与墨西哥裔美国儿童肥胖程度较高呈负相关。

Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children.

作者信息

Gunanti Inong R, Marks Geoffrey C, Al-Mamun Abdullah, Long Kurt Z

机构信息

School of Population Health, The University of Queensland, Herston, Australia; and.

School of Population Health, The University of Queensland, Herston, Australia; and Department of Epidemiology and Public Health, Swiss Tropical Institute of Public Health, Basel, Switzerland

出版信息

J Nutr. 2014 Dec;144(12):2027-33. doi: 10.3945/jn.114.201202. Epub 2014 Oct 8.

DOI:10.3945/jn.114.201202

PMID:25411037

Abstract

BACKGROUND

Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however, have reported inconsistent findings.

OBJECTIVE

The aim of the study was to examine associations between serum vitamin B-12 and folate concentrations and intakes of B vitamins with body fat by using data on 1131 Mexican American children 8-15 y of age included in NHANES 2001-2004.

METHODS

Children's body mass index (BMI), trunk fat mass (TrFM), and total body fat mass (TBFM) were used as body adiposity (BA) measures. Serum concentrations of folate and vitamin B-12 were measured in blood samples collected from children. Intake of B vitamins was collected according to 24-h dietary recall. Associations of BA with serum concentrations of vitamin B-12 and folate and intake of B vitamins were determined by using linear and multinomial regression models.

RESULTS

Serum concentrations of vitamin B-12 and folate were inversely associated with BMI (β: -2.68, P < 0.01; β = -1.33, P < 0.01), TrFM (β:-3.32, P < 0.01; β: -0.14, P < 0.05), and TBFM (β:-1.93, P < 0.01; β: -3.19; P < 0.01). Higher serum concentrations of vitamin B-12 were associated with a reduced risk of obesity (OR: 0.48; 95% CI: 0.31, 0.77; P < 0.001). Thiamin and riboflavin intakes were inversely associated with BMI (β:-1.35, P < 0.05; β: -1.11, P < 0.05) and TrFM (β:-1.26, P < 0.05; β: -1.37, P < 0.05).

CONCLUSION

Similar inverse associations between BA and status of both vitamin B-12 and folate and intake of thiamin and riboflavin suggest that these micronutrients may play a role in adipogenesis and risk of childhood obesity.

摘要

背景

在许多正经历营养转型的工业化国家，微量营养素状况可能是儿童肥胖症发展的一个促成因素。然而，少数研究维生素B血清浓度和B族维生素摄入量与肥胖之间关联的报告结果并不一致。

目的

本研究旨在利用2001 - 2004年美国国家健康与营养检查调查（NHANES）中1131名8 - 15岁墨西哥裔美国儿童的数据，研究血清维生素B - 12和叶酸浓度以及B族维生素摄入量与体脂之间的关联。

方法

儿童的体重指数（BMI）、躯干脂肪量（TrFM）和全身脂肪量（TBFM）被用作身体肥胖（BA）指标。从儿童采集的血样中测量叶酸和维生素B - 12的血清浓度。根据24小时饮食回顾收集B族维生素的摄入量。通过线性和多项回归模型确定BA与维生素B - 12和叶酸的血清浓度以及B族维生素摄入量之间的关联。

结果

维生素B - 12和叶酸的血清浓度与BMI呈负相关（β：-2.68，P < 0.01；β = -1.33，P < 0.01）、与TrFM呈负相关（β：-3.32，P < 0.01；β：-0.14，P < 0.05）以及与TBFM呈负相关（β：-1.93，P < 0.01；β：-3.19；P < 0.01）。较高的维生素B - 12血清浓度与肥胖风险降低相关（OR：0.48；95% CI：0.31，0.77；P < 0.001）。硫胺素和核黄素摄入量与BMI呈负相关（β：-1.35，P < 0.05；β：-1.11，P < 0.05）以及与TrFM呈负相关（β：-1.26，P < 0.05；β：-1.37，P < 0.05）。