人类免疫缺陷病毒感染的生物学与流行病学

The biology and epidemiology of HIV infections.

作者信息

Weber J

机构信息

Department of Medicine, Royal Post-graduate Medical School, Hammersmith Hospital, London, UK.

出版信息

J Antimicrob Chemother. 1989 Jan;23 Suppl A:1-7. doi: 10.1093/jac/23.suppl_a.1.

DOI:10.1093/jac/23.suppl_a.1

PMID:2541125

Abstract

The world now has a pandemic of infection by the human immunodeficiency virus type I (HIV-1). More recently, a focus of epidemic HIV-2 infection in West Africa has been noted and this too is spreading internationally. HIV-2 closely resembles a simian lentivirus, SIV; SIV isolates have now been made from African (but not Asian) old world monkeys and SIV infection in macaques may provide the best animal model for HIV. All of these viruses share a tropism for the CD4 molecule, which is intimately involved in their pathogenesis. The immune response to these viruses has yet to demonstrate any protective immunity.

摘要

目前，世界正面临着由I型人类免疫缺陷病毒（HIV-1）引发的大流行感染。最近，西非出现了HIV-2感染的流行焦点，并且这种病毒也正在向国际范围传播。HIV-2与一种猿猴慢病毒——猴免疫缺陷病毒（SIV）极为相似；现在已从非洲（而非亚洲）的旧大陆猴中分离出SIV毒株，猕猴感染SIV可能为HIV提供最佳动物模型。所有这些病毒都对CD4分子具有嗜性，而CD4分子与其发病机制密切相关。针对这些病毒的免疫反应尚未显示出任何保护性免疫。