Levine P H, Fisher M, Schneider P B, Whitten R H, Weiner B H, Ockene I S, Johnson B F, Johnson M H, Doyle E M, Riendeau P A
Department of Medicine, Worcester Memorial Hospital, MA 01605.
Arch Intern Med. 1989 May;149(5):1113-6.
Enhanced dietary omega-3 fatty acid consumption is thought to be associated with a reduced incidence of atherothrombotic disorders. This effect may be mediated in part through suppression of in vivo platelet activity by omega-3 fatty acids. We observed that platelet survival, a sensitive indicator of in vivo platelet activity was prolonged from 6.4 +/- 1.5 days to 7.7 +/- 1.4 days by moderate amounts of dietary omega-3 fatty acid supplementation for 6 weeks in a group of hyperlipidemic patients with preexisting, established atherothrombotic disorders. This effect on platelet survival was associated with a decrease in platelet arachidonic acid levels from 26.7 +/- 3.5% to 20.9% +/- 2.5% and a rise in platelet eicosapentaenoic and docosahexaenoic acid measurements from essentially undetectable to 2.8% +/- 1.6% and 1.9% +/- 1.0%. Plasma total cholesterol, low-density lipoprotein cholesterol, and serum apolipoprotein B levels rose significantly during the omega-3 fatty acid supplementation period. Platelet aggregation did not change. This study demonstrates that a modest amount of dietary omega-3 fatty acid supplementation can significantly effect in vivo platelet activity in a population at high risk for recurrent atherothrombotic disorders.
增加膳食中ω-3脂肪酸的摄入量被认为与动脉粥样硬化血栓形成疾病的发病率降低有关。这种作用可能部分是通过ω-3脂肪酸抑制体内血小板活性来介导的。我们观察到，在一组患有已确诊的动脉粥样硬化血栓形成疾病的高脂血症患者中，通过适度补充膳食ω-3脂肪酸6周，血小板存活时间（体内血小板活性的敏感指标）从6.4±1.5天延长至7.7±1.4天。这种对血小板存活时间的影响与血小板花生四烯酸水平从26.7±3.5%降至20.9%±2.5%以及血小板二十碳五烯酸和二十二碳六烯酸水平从基本检测不到升至2.8%±1.6%和1.9%±1.0%有关。在补充ω-3脂肪酸期间，血浆总胆固醇、低密度脂蛋白胆固醇和血清载脂蛋白B水平显著升高。血小板聚集未发生变化。这项研究表明，适度补充膳食ω-3脂肪酸可显著影响复发动脉粥样硬化血栓形成疾病高危人群的体内血小板活性。
