Kakar Puneet, Watson Timothy, Lip Gregory Y H
University Department of Medicine, City Hospital, Birmingham B18 7QH, UK.
Curr Atheroscler Rep. 2008 Feb;10(1):79-87. doi: 10.1007/s11883-008-0012-4.
With greater focus on chronic disease prevention, renewed attention has been directed toward understanding the pathophysiology of various medical conditions and the development of newer medical treatments to prevent and treat complications. There has been immense interest in evaluating societal lifestyles, cultural attitudes toward health, and dietary influences on health conditions. The omega-3 fatty acids have become a focus of interest, and recent research and trial evidence have highlighted their effects, including potential clinical advantages. Despite this progress, the precise mechanisms through which omega-3 fatty acids act remain poorly understood. These agents are now recommended as secondary prevention after acute myocardial infarction, and ongoing large clinical trials should provide insight into the use of omega-3 fatty acids in heart failure and the primary prevention of cardiovascular disease.
随着对慢性病预防的关注度不断提高，人们重新将注意力转向了解各种疾病的病理生理学以及开发预防和治疗并发症的新型医学疗法。评估社会生活方式、文化对健康的态度以及饮食对健康状况的影响引发了极大的兴趣。ω-3脂肪酸已成为关注焦点，近期的研究和试验证据凸显了它们的作用，包括潜在的临床优势。尽管取得了这一进展，但ω-3脂肪酸发挥作用的确切机制仍知之甚少。这些药物目前被推荐用于急性心肌梗死后的二级预防，正在进行的大型临床试验应能深入了解ω-3脂肪酸在心力衰竭中的应用以及心血管疾病的一级预防。
