Wang Kun, Li Wei, Rui Xin, Li Teng, Chen Xiaohong, Jiang Mei, Dong Mingsheng
College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang Road, Nanjing, Jiangsu, People's Republic of China.
Glycoconj J. 2015 Feb;32(1-2):17-27. doi: 10.1007/s10719-014-9567-1. Epub 2014 Nov 23.
In the present study, a released exopolysaccharide (r-EPS1) from L. plantarum 70810 was modified by acetylation, phosphorylation and carboxymethylation. Scanning electron micrograph (SEM) and thermogravimetric analysis (TGA) showed the r-EPS1 derivatives had different surface morphology and thermal behavior. Compared with r-EPS1, the derivatives exhibited stronger antioxidant and antitumor activities. The study provided experimental evidences that chemical modification could be an effective way to improve the bioactivity of exopolysaccharide from L. plantarum 70810. It is noted that these derivatives could be explored as novel potential antioxidant and antitumor agents.
在本研究中,植物乳杆菌70810分泌的一种胞外多糖(r-EPS1)经乙酰化、磷酸化和羧甲基化修饰。扫描电子显微镜(SEM)和热重分析(TGA)表明,r-EPS1衍生物具有不同的表面形态和热行为。与r-EPS1相比,这些衍生物表现出更强的抗氧化和抗肿瘤活性。该研究提供了实验证据,表明化学修饰可能是提高植物乳杆菌70810胞外多糖生物活性的有效方法。值得注意的是,这些衍生物可作为新型潜在的抗氧化和抗肿瘤剂进行探索。