Suppr超能文献

衰老学:将衰老与慢性疾病联系起来。

Geroscience: linking aging to chronic disease.

机构信息

Buck Institute for Research on Aging, Novato, CA USA.

Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

摘要

哺乳动物的衰老可以通过遗传、饮食和药物方法来延缓。鉴于老年人口数量的急剧增加,以及衰老是导致大多数导致发病率和死亡率的慢性疾病的最大风险因素,扩大旨在延长人类健康寿命的衰老科学研究至关重要。

相似文献

1
Geroscience: linking aging to chronic disease.
Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.
2
Geroscience and the trans-NIH Geroscience Interest Group, GSIG.
Geroscience. 2017 Feb;39(1):1-5. doi: 10.1007/s11357-016-9954-6.
3
Advances in geroscience: impact on healthspan and chronic disease.
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1(Suppl 1):S1-3. doi: 10.1093/gerona/glu041.
4
Geroscience and pathology: a new frontier in understanding age-related diseases.
Pathol Oncol Res. 2024 Feb 23;30:1611623. doi: 10.3389/pore.2024.1611623. eCollection 2024.
5
Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.
J Am Coll Cardiol. 2023 Aug 15;82(7):631-647. doi: 10.1016/j.jacc.2023.05.038. Epub 2023 Jun 28.
6
The Role of the National Institute on Aging in the Development of the Field of Geroscience.
Cold Spring Harb Perspect Med. 2023 Oct 3;13(10):a041211. doi: 10.1101/cshperspect.a041211.
7
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span.
Cold Spring Harb Perspect Med. 2016 Apr 1;6(4):a025163. doi: 10.1101/cshperspect.a025163.
8
GeroScience: understanding the interaction of processes of aging and chronic diseases.
Age (Dordr). 2016 Dec;38(5-6):377-378. doi: 10.1007/s11357-016-9953-7.
9
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging.
Geroscience. 2021 Oct;43(5):2129-2137. doi: 10.1007/s11357-021-00421-2. Epub 2021 Jul 23.
10
Geroscience approaches to increase healthspan and slow aging.
F1000Res. 2016 Apr 29;5. doi: 10.12688/f1000research.7583.1. eCollection 2016.

引用本文的文献

4
Reversible ALKBH5 cytosolic aggregation accelerates cellular senescence.
Cell Death Differ. 2025 Aug 15. doi: 10.1038/s41418-025-01560-1.
5
Understanding and improving vaccine efficacy in older adults.
Nat Aging. 2025 Aug;5(8):1455-1470. doi: 10.1038/s43587-025-00939-6. Epub 2025 Aug 14.
8
Mechanobiology of the blood-brain barrier during development, disease and ageing.
Nat Commun. 2025 Aug 6;16(1):7233. doi: 10.1038/s41467-025-61888-7.
9
Dying occurs as a defined molecular progression in rather than as nonspecific physiological collapse.
iScience. 2025 Jul 14;28(8):113115. doi: 10.1016/j.isci.2025.113115. eCollection 2025 Aug 15.
10
Dynamics of multimorbidity, health expectancy, and survival in middle aged and older individuals.
J Gerontol A Biol Sci Med Sci. 2025 Aug 23;80(9). doi: 10.1093/gerona/glaf164.

本文引用的文献

1
Stem cells as vehicles for youthful regeneration of aged tissues.
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1(Suppl 1):S39-42. doi: 10.1093/gerona/glu043.
2
You are what you host: microbiome modulation of the aging process.
Cell. 2014 Jan 30;156(3):408-11. doi: 10.1016/j.cell.2014.01.025.
3
Drugs that modulate aging: the promising yet difficult path ahead.
Transl Res. 2014 May;163(5):456-65. doi: 10.1016/j.trsl.2013.11.007. Epub 2013 Nov 20.
4
Survivors of childhood and adolescent cancer: life-long risks and responsibilities.
Nat Rev Cancer. 2014 Jan;14(1):61-70. doi: 10.1038/nrc3634. Epub 2013 Dec 5.
5
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
Aging Cell. 2014 Apr;13(2):273-82. doi: 10.1111/acel.12170. Epub 2013 Nov 19.
6
Is HIV a model of accelerated or accentuated aging?
J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):833-42. doi: 10.1093/gerona/glt168. Epub 2013 Oct 24.
7
Metformin improves healthspan and lifespan in mice.
Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192.
8
The hallmarks of aging.
Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.
10
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.
Bioessays. 2013 Apr;35(4):386-96. doi: 10.1002/bies.201200148. Epub 2013 Feb 19.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验