Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Cell. 2014 Nov 6;159(4):956-956.e1. doi: 10.1016/j.cell.2014.10.045.
The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.
哺乳动物的 sirtuins 已成为细胞应激抗性、能量代谢和肿瘤发生的关键调节因子。在某些情况下,它们可以延缓与年龄相关疾病的发生,并促进健康的寿命。虽然哺乳动物的七个 sirtuins(SIRT1-7)具有高度保守的 NAD+-结合催化核心结构域,但它们表现出不同的表达模式、催化活性和生物学功能。这篇 SnapShot 概述了这些特性,并强调了它们与衰老的相关性。