使用银（I）三氟甲硫醇盐和四丁基碘化铵直接对醇进行去羟三氟甲基化反应。
Direct dehydroxytrifluoromethylthiolation of alcohols using silver(I) trifluoromethanethiolate and tetra-n-butylammonium iodide.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032 (China).
出版信息
Angew Chem Int Ed Engl. 2015 Jan 12;54(3):897-900. doi: 10.1002/anie.201409983. Epub 2014 Nov 24.
An unprecedented reaction for the direct trifluoromethylthiolation and fluorination of alkyl alcohols using AgSCF3 and nBu4NI has been developed. The trifluoromethylthiolated compounds and alkyl fluorides were selectively formed by changing the ratio of AgSCF3/nBu4NI. This protocol is tolerant of different functional groups and might be applicable to late-stage trifluoromethylthiolation of alcohols.
一种前所未有的反应，使用 AgSCF3 和 nBu4NI 直接对烷基醇进行三氟甲硫基化和氟化，已经被开发出来。通过改变 AgSCF3/nBu4NI 的比例，可以选择性地形成三氟甲硫基化合物和烷基氟化物。该方案对不同的官能团具有耐受性，可能适用于醇的后期三氟甲硫基化。
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