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1
Evidence that proteins S1, S11 and S21 directly participates in the binding of transfer RNA to the 30S ribosome.有证据表明蛋白质S1、S11和S21直接参与转运RNA与30S核糖体的结合。
Nucleic Acids Res. 1978 Mar;5(3):933-50. doi: 10.1093/nar/5.3.933.
2
[Study of the photoaffinity modification of Escherichia coli ribosomes near the donor tRNA-binding center].[大肠杆菌核糖体供体tRNA结合中心附近的光亲和修饰研究]
Mol Biol (Mosk). 1985 Mar-Apr;19(2):545-52.
3
On the role of protein S4 N-terminal residues 1 through 30 in 30S ribosome function.关于蛋白质S4 N端1至30位残基在30S核糖体功能中的作用
Nucleic Acids Res. 1978 Aug;5(8):2789-99. doi: 10.1093/nar/5.8.2789.
4
The effect of aminoacyl- or peptidyl-tRNA at the A-site on the arrangement of deacylated tRNA at the ribosomal P-site.A位点上氨酰基或肽基tRNA对核糖体P位点上脱酰基tRNA排列的影响。
FEBS Lett. 1984 May 21;170(2):290-4. doi: 10.1016/0014-5793(84)81330-7.
5
Nucleotide residues of tRNA, directly interacting with proteins within the complex of the 30 S subunit of E. coli ribosome with poly(U) and NAcPhe-tRNA(Phe).与大肠杆菌核糖体30 S亚基与聚（U）和NAcPhe - tRNA（Phe）形成的复合物中的蛋白质直接相互作用的tRNA核苷酸残基。
FEBS Lett. 1989 Jan 30;243(2):299-302. doi: 10.1016/0014-5793(89)80149-8.
6
The proteins of the messenger RNA binding site of Escherichia coli ribosomes.大肠杆菌核糖体信使核糖核酸结合位点的蛋白质
Nucleic Acids Res. 1981 Jul 24;9(14):3465-81. doi: 10.1093/nar/9.14.3465.
7
[Contacts of ribosomal proteins with tRNAPhe and 16S RNA in analogs of the 30S initiation complex].[核糖体蛋白与30S起始复合物类似物中苯丙氨酰tRNA及16S RNA的相互作用]
Mol Biol (Mosk). 1985 Mar-Apr;19(2):553-7.
8
[Proteins contacting with peptidyl-tRNA at the A-site of the Escherichia coli ribosome after enzymatic and non-enzymatic binding of aminoacyl-tRNA].[在氨酰-tRNA进行酶促和非酶促结合后，与大肠杆菌核糖体A位点的肽基-tRNA接触的蛋白质]
Mol Biol (Mosk). 1985 Jul-Aug;19(4):1148-52.
9
[Nature of the heterogeneity of the 30S ribosomal subunits in vitro. II. Two types of inactivation of the 30S subunits of Escherichia coli ribosomes].[体外30S核糖体亚基的异质性本质。II. 大肠杆菌核糖体30S亚基的两种失活类型]
Mol Biol (Mosk). 1979 Jul-Aug;13(4):752-60.
10
Ribosomal protein S1 and polypeptide chain initiation in bacteria.细菌中的核糖体蛋白S1与多肽链起始
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2325-9. doi: 10.1073/pnas.72.6.2325.

引用本文的文献

1
Ribosomal protein S14 of Saccharomyces cerevisiae regulates its expression by binding to RPS14B pre-mRNA and to 18S rRNA.酿酒酵母的核糖体蛋白S14通过与RPS14B前体mRNA和18S rRNA结合来调节其表达。
Mol Cell Biol. 1999 Jan;19(1):826-34. doi: 10.1128/MCB.19.1.826.
2
Comparative study of the interaction of polyuridylic acid with 30S subunits and 70S ribosomes of Escherichia coli.聚尿苷酸与大肠杆菌30S亚基和70S核糖体相互作用的比较研究。
Nucleic Acids Res. 1980 Jan 25;8(2):403-21. doi: 10.1093/nar/8.2.403.
3
Mechanism of codon-anticodon interaction in ribosomes. Direct functional evidence that isolated 30S subunits contain two codon-specific binding sites for transfer RNA.核糖体中密码子与反密码子相互作用的机制。分离的30S亚基含有两个用于转运RNA的密码子特异性结合位点的直接功能证据。
Nucleic Acids Res. 1980 Jan 11;8(1):183-96. doi: 10.1093/nar/8.1.183.
4
Elongation factor Tu-induced conformational changes of ribosomes detected by iodination.通过碘化检测延伸因子Tu诱导的核糖体构象变化。
Mol Biol Rep. 1979 Aug 31;5(3):193-6. doi: 10.1007/BF00778423.
5
Localization of the decoding region on the 30S Escherichia coli ribosomal subunit by affinity immunoelectron microscopy.通过亲和免疫电子显微镜对大肠杆菌30S核糖体亚基上解码区域的定位
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1054-8. doi: 10.1073/pnas.76.3.1054.

本文引用的文献

1
THE CHROMOSOMAL SITE SPECIFYING A RIBOSOMAL PROTEIN IN ESCHERICHIA COLI.大肠杆菌中指定核糖体蛋白的染色体位点。
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1367-74. doi: 10.1073/pnas.52.6.1367.
2
RNA CODEWORDS AND PROTEIN SYNTHESIS. THE EFFECT OF TRINUCLEOTIDES UPON THE BINDING OF SRNA TO RIBOSOMES.RNA密码子与蛋白质合成。三核苷酸对可溶性核糖核酸（sRNA）与核糖体结合的影响。
Science. 1964 Sep 25;145(3639):1399-407. doi: 10.1126/science.145.3639.1399.
3
Reaction of tetranitromethane with protein sulfhydryl groups. Inactivation of aldolase.四硝基甲烷与蛋白质巯基的反应。醛缩酶的失活。
Biochemistry. 1968 Apr;7(4):1525-30. doi: 10.1021/bi00844a040.
4
Stoichiometry of the 30S ribosomal proteins of Escherichia coli.大肠杆菌30S核糖体蛋白的化学计量学
Biochemistry. 1971 Feb 2;10(3):517-24. doi: 10.1021/bi00779a026.
5
Tetranitromethane. A reagent for the nitration of tyrosyl residues in proteins.四硝基甲烷。一种用于蛋白质中酪氨酸残基硝化的试剂。
Biochemistry. 1966 Nov;5(11):3582-9. doi: 10.1021/bi00875a029.
6
The requirements for specific sRNA binding by ribosomes.核糖体对特定小RNA（sRNA）结合的要求。
J Mol Biol. 1966 Jun;18(1):90-108. doi: 10.1016/s0022-2836(66)80079-7.
7
Correlation of 30S ribosomal proteins of Escherichia coli isolated in different laboratories.不同实验室分离的大肠杆菌30S核糖体蛋白的相关性
Mol Gen Genet. 1971;111(4):327-33. doi: 10.1007/BF00569784.
8
Ribosomal discrimination of tRNAs.核糖体对转运RNA的识别
Nat New Biol. 1971 Dec 29;234(52):261-4. doi: 10.1038/newbio234261a0.
9
Three-dimensional organization of the 30S ribosomal proteins from Escherichia coli. I. Preliminary classification of the proteins.大肠杆菌30S核糖体蛋白的三维结构。I. 蛋白质的初步分类。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1329-36. doi: 10.1073/pnas.67.3.1329.
10
Assembly mapping of 30S ribosomal proteins from E. coli.来自大肠杆菌的30S核糖体蛋白的装配图谱
Nature. 1970 Jun 27;226(5252):1214. doi: 10.1038/2261214a0.

有证据表明蛋白质S1、S11和S21直接参与转运RNA与30S核糖体的结合。

Evidence that proteins S1, S11 and S21 directly participates in the binding of transfer RNA to the 30S ribosome.

作者信息

Fanning T G, Cantrell M, Shih C Y, Craven G R

出版信息

Nucleic Acids Res. 1978 Mar;5(3):933-50. doi: 10.1093/nar/5.3.933.

DOI:10.1093/nar/5.3.933
PMID:25421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342034/
Abstract

In a previous publication1 we reported that the tyrosine selective reagent, tetraitromethane, causes complete inactivation of E. coli 30S ribosomes for poly U directed non-enzymatic phe-tRNA binding. This inactivation was demonstrated to be due to the chemical modification of the protein moiety of the ribosome. We have no identified the proteins of the 30S particle inactivated by this modification. Using a method of ribosome reconstruction we have found that unmodified proteins S1, S11, and S21 are essential for the restoration of the phe-tRNA binding activity of tetranitromethane inactivated ribosomes. We propose that these three proteins are intimately involved in the 30S ribosome binding site for tRNA.

摘要

在之前的一篇出版物1中，我们报道酪氨酸选择性试剂四硝基甲烷会导致大肠杆菌30S核糖体完全失活，从而无法进行聚U指导的非酶促苯丙氨酰-tRNA结合。这种失活被证明是由于核糖体蛋白质部分的化学修饰所致。我们尚未鉴定出因这种修饰而失活的30S颗粒中的蛋白质。通过核糖体重建方法，我们发现未修饰的蛋白质S1、S11和S21对于恢复四硝基甲烷失活核糖体的苯丙氨酰-tRNA结合活性至关重要。我们提出这三种蛋白质密切参与了30S核糖体与tRNA的结合位点。