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Two types of optical coherence tomographic images of retinal pigment epithelial detachments with different prognosis.具有不同预后的视网膜色素上皮脱离的两种光学相干断层扫描图像。
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2型膜增生性肾小球肾炎中布鲁赫膜的高速超高分辨率光学相干断层扫描

High-speed ultrahigh-resolution OCT of Bruch's membrane in membranoproliferative glomerulonephritis type 2.

作者信息

Adhi Mehreen, Read Sarah P, Liu Jonathan J, Fujimoto James G, Duker Jay S

出版信息

Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec;45(6):614-7. doi: 10.3928/23258160-20141118-20.

DOI:10.3928/23258160-20141118-20
PMID:25423645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4712916/
Abstract

Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

摘要

2型膜增生性肾小球肾炎（MPGN）的特征是肾小球基底膜中有电子致密沉积物，以及布鲁赫膜中有玻璃膜疣样沉积物。随着时间的推移，视网膜和视网膜色素上皮会出现萎缩性变化，进而可能发展为脉络膜新生血管（CNV）。本报告描述了一名2型MPGN患者，其因CNV导致视力逐渐丧失。高速超高分辨率光学相干断层扫描（UHR-OCT）显示，在黄斑中心下方10μm处的布鲁赫膜不规则。高速UHR-OCT有可能用于分析2型MPGN等疾病的继发性眼部表现以及年龄相关性黄斑变性等原发性视网膜疾病中的布鲁赫膜。