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[II型膜增生性肾小球肾炎患者:玻璃体内注射贝伐单抗治疗脉络膜新生血管]

[Patient with type II membranoproliferative glomerulonephritis: intravitreal bevacizumab therapy for choroidal neovascularization].

作者信息

Karampelas M, Kopsachilis N, Chang J H, Pal B

机构信息

Moorfields Eye Hospital, 162 City Road, London, UK.

出版信息

Ophthalmologe. 2012 Aug;109(8):791-3. doi: 10.1007/s00347-012-2550-y.

Abstract

Membranoproliferative glomerulonephritis (MPGN) type II is a rare disease characterized by electron dense deposits on the basement membrane in the glomeruli of the kidneys and also in Bruch's membrane of the eye. Although most patients have asymptomatic drusen of the retina choroidal neovascularization can sometimes develop, which can permanently affect visual acuity. We report an unusual case of choroidal neovascularization in a patient with MPGN type II that was successfully treated with a single intravitreal injection of bevacizumab. The 6 months follow-up showed no recurrence of choroidal neovascularization.

摘要

II型膜增生性肾小球肾炎(MPGN)是一种罕见疾病,其特征是在肾脏肾小球的基底膜以及眼部的布鲁赫膜上有电子致密沉积物。虽然大多数患者有视网膜无症状性玻璃膜疣,但有时会发生脉络膜新生血管形成,这可能会永久性地影响视力。我们报告了一例II型MPGN患者发生脉络膜新生血管形成的罕见病例,该患者通过玻璃体内单次注射贝伐单抗成功治疗。6个月的随访显示脉络膜新生血管形成未复发。

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