State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, PR China.
Adv Mater. 2015 Jan 14;27(2):215-22. doi: 10.1002/adma.201404256. Epub 2014 Nov 25.
A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).
一种新颖的胶束/前体共模板组装策略被成功开发，用于合成大孔超小介孔有机硅纳米粒子（MONs）。此外，还构建了经过精心设计的具有细胞穿透肽（TAT）的 MONs（MONs-PTAT），用于高效的核内基因传递。它们具有高载药量、改善了负载基因的保护作用，并提高了 EGFP 质粒（pEGFP）的转染效率。
