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本文引用的文献

1
Two novel toxin variants revealed by whole-genome sequencing of 175 Clostridium botulinum type E strains.通过对175株E型肉毒杆菌进行全基因组测序揭示了两种新型毒素变体。
Appl Environ Microbiol. 2014 Oct;80(20):6334-45. doi: 10.1128/AEM.01573-14. Epub 2014 Aug 8.
2
An atypical Clostridium strain related to the Clostridium botulinum group III strain isolated from a human blood culture.从人血培养物中分离出的与肉毒梭菌 III 群相关的非典型梭状芽胞杆菌菌株。
J Clin Microbiol. 2014 Jan;52(1):339-43. doi: 10.1128/JCM.00390-13. Epub 2013 Oct 2.
3
Application of high-density DNA resequencing microarray for detection and characterization of botulinum neurotoxin-producing clostridia.应用高密度 DNA 重测序微阵列检测和鉴定产肉毒梭菌神经毒素的梭菌。
PLoS One. 2013 Jun 20;8(6):e67510. doi: 10.1371/journal.pone.0067510. Print 2013.
4
Genomic and physiological variability within Group II (non-proteolytic) Clostridium botulinum.组 II(非蛋白水解)肉毒梭菌的基因组和生理变异性。
BMC Genomics. 2013 May 16;14:333. doi: 10.1186/1471-2164-14-333.
5
What next for botulism vaccine development?肉毒杆菌毒素疫苗的开发有哪些新进展?
Expert Rev Vaccines. 2013 May;12(5):481-92. doi: 10.1586/erv.13.37.
6
Genetic diversity of the flagellin genes of Clostridium botulinum groups I and II.肉毒梭菌 I 型和 II 型鞭毛蛋白基因的遗传多样性。
Appl Environ Microbiol. 2013 Jul;79(13):3926-32. doi: 10.1128/AEM.00686-13. Epub 2013 Apr 19.
7
Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes.肉毒梭菌血清型、肉毒神经毒素基因簇和毒素亚型的遗传多样性。
Curr Top Microbiol Immunol. 2013;364:1-20. doi: 10.1007/978-3-642-33570-9_1.
8
Analysis of a unique Clostridium botulinum strain from the Southern hemisphere producing a novel type E botulinum neurotoxin subtype.分析一株来自南半球的独特肉毒梭菌菌株,该菌株产生一种新型 E 型肉毒神经毒素亚型。
BMC Microbiol. 2012 Oct 31;12:245. doi: 10.1186/1471-2180-12-245.
9
Neurotoxin gene profiling of clostridium botulinum types C and D native to different countries within Europe.神经毒素基因谱分析欧洲不同国家本土的 C 型和 D 型肉毒梭菌。
Appl Environ Microbiol. 2012 May;78(9):3120-7. doi: 10.1128/AEM.07568-11. Epub 2012 Feb 17.
10
Analysis of Clostridium botulinum serotype E strains by using multilocus sequence typing, amplified fragment length polymorphism, variable-number tandem-repeat analysis, and botulinum neurotoxin gene sequencing.采用多位点序列分型、扩增片段长度多态性、可变数串联重复分析和肉毒神经毒素基因测序对 E 型肉毒梭菌进行分析。
Appl Environ Microbiol. 2011 Dec;77(24):8625-34. doi: 10.1128/AEM.05155-11. Epub 2011 Oct 14.

由火腿中的B型和E型肉毒梭菌引起的非典型食源性肉毒中毒暴发。

An atypical outbreak of food-borne botulism due to Clostridium botulinum types B and E from ham.

作者信息

Mazuet Christelle, Sautereau Jean, Legeay Christine, Bouchier Christiane, Bouvet Philippe, Popoff Michel R

机构信息

Institut Pasteur, Bactéries Anaérobies et Toxines, Paris, France.

Institut Pasteur, Plateforme Génomique, Paris, France.

出版信息

J Clin Microbiol. 2015 Feb;53(2):722-6. doi: 10.1128/JCM.02942-14. Epub 2014 Nov 26.

DOI:10.1128/JCM.02942-14
PMID:25428161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4298549/
Abstract

An outbreak of human botulism was due to consumption of ham containing botulinum neurotoxins B and E. A Clostridium botulinum type E strain isolated from ham was assigned to a new subtype (E12) based on bont/E gene sequencing and belongs to a new multilocus sequence subtype, as analyzed by whole-genome sequencing.

摘要

一起人类肉毒中毒事件是由于食用了含有肉毒杆菌神经毒素B和E的火腿所致。从火腿中分离出的一株E型肉毒梭菌,经肉毒杆菌神经毒素E(bont/E)基因测序后被归为一个新的亚型(E12),并且通过全基因组测序分析,它属于一个新的多位点序列亚型。