Shaw Christopher A, Li Dan, Tomljenovic Lucija
Neural Dynamics Research Group, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada.
Immunotherapy. 2014;6(10):1055-71. doi: 10.2217/imt.14.81.
In spite of a common view that aluminum (Al) salts are inert and therefore harmless as vaccine adjuvants or in immunotherapy, the reality is quite different. In the following article we briefly review the literature on Al neurotoxicity and the use of Al salts as vaccine adjuvants and consider not only direct toxic actions on the nervous system, but also the potential impact for triggering autoimmunity. Autoimmune and inflammatory responses affecting the CNS appear to underlie some forms of neurological disease, including developmental disorders. Al has been demonstrated to impact the CNS at every level, including by changing gene expression. These outcomes should raise concerns about the increasing use of Al salts as vaccine adjuvants and for the application as more general immune stimulants.
尽管人们普遍认为铝盐是惰性的，因此作为疫苗佐剂或用于免疫治疗是无害的，但实际情况却大不相同。在接下来的文章中，我们简要回顾了关于铝神经毒性以及铝盐作为疫苗佐剂使用的文献，并不仅考虑其对神经系统的直接毒性作用，还考虑其引发自身免疫的潜在影响。影响中枢神经系统的自身免疫和炎症反应似乎是包括发育障碍在内的某些神经系统疾病的基础。铝已被证明在各个层面都会影响中枢神经系统，包括通过改变基因表达。这些结果应该引起人们对铝盐作为疫苗佐剂的使用日益增加以及作为更普遍的免疫刺激剂应用的担忧。
