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XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk.XRCC2 R188H(rs3218536)、XRCC3 T241M(rs861539)和 R243H(rs77381814)单核苷酸多态性与宫颈癌风险的关系。
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Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.同源重组修复基因 RAD51、XRCC2 和 XRCC3 多态性与结直肠癌的关系——病例对照研究。
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DNA修复基因XRCC2和XRCC3的多态性与土耳其胃癌风险

Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey.

作者信息

Gok Ilhami, Baday Meryem, Cetinkunar Suleyman, Kilic Kemal, Bilgin Bulent Caglar

机构信息

Department of Bioengineering, Faculty of Engineering & Architecture Kafkas University, 36100 Kars/ Turkey Phone: Fax : +90 474 225 12 82.

出版信息

Bosn J Basic Med Sci. 2014 Sep 13;14(4):214-8. doi: 10.17305/bjbms.2014.4.7.

DOI:10.17305/bjbms.2014.4.7
PMID:25428673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4333970/
Abstract

We studied the prevalence of polymorphisms in genes XRCC2 and XRCC3 in stomach cancer patients who lived in North Eastern Turkey. A total of 61 cancer patients and 78 controls were included in this study. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met. Blood samples were taken from the patients and controls, and DNA was isolated. The regions of interest were amplified using a polymerase chain reaction method. After amplification, we used restriction enzymes (HphI and NcoI) to digest the amplified product. Digested product was then run through gel electrophoresis. We identified changes in the nucleotides in these specific regions. It was found that the Arg188His polymorphism of the XRCC2 gene was about 39% (24 out of the 61) among cancer patients. However, only 15% (12 out of 78) of the control group indicated this polymorphism. We also observed that 18 of the 61 cancer patients (29%) carried the Thr241Met polymorphism of the XRCC3 gene whereas 11 of the 78 (14%) individuals in the control group had the polymorphism. Our results showed a significant difference in polymorphism ratios between the cancer patients and health control group for the regions of interest. This result clearly showed that these polymorphisms increase the risk of stomach cancer and might be a strong marker for early diagnosis of gastric cancer.

摘要

我们研究了居住在土耳其东北部的胃癌患者中XRCC2和XRCC3基因多态性的患病率。本研究共纳入61例癌症患者和78例对照。研究了XRCC2和XRCC3基因在Arg188His和Thr241Met位点的单核苷酸变化。从患者和对照中采集血样，并分离DNA。使用聚合酶链反应方法扩增感兴趣的区域。扩增后，我们使用限制性内切酶（HphI和NcoI）消化扩增产物。然后将消化产物进行凝胶电泳。我们确定了这些特定区域核苷酸的变化。发现XRCC2基因的Arg188His多态性在癌症患者中约为39%（61例中有24例）。然而，对照组中只有15%（78例中有12例）显示出这种多态性。我们还观察到，61例癌症患者中有18例（29%）携带XRCC3基因的Thr241Met多态性，而对照组78例中有11例（14%）个体具有该多态性。我们的结果显示，癌症患者和健康对照组在感兴趣区域的多态性比率存在显著差异。这一结果清楚地表明，这些多态性增加了患胃癌的风险，可能是胃癌早期诊断的一个有力标志物。