生物安全纳米级药物佐剂材料。
Biosafe nanoscale pharmaceutical adjuvant materials.
出版信息
J Biomed Nanotechnol. 2014 Sep;10(9):2393-419. doi: 10.1166/jbn.2014.1898.
Abstract
Thanks to developments in the field of nanotechnology over the past decades, more and more biosafe nanoscale materials have become available for use as pharmaceutical adjuvants in medical research. Nanomaterials possess unique properties which could be employed to develop drug carriers with longer circulation time, higher loading capacity, better stability in physiological conditions, controlled drug release, and targeted drug delivery. In this review article, we will review recent progress in the application of representative organic, inorganic and hybrid biosafe nanoscale materials in pharmaceutical research, especially focusing on nanomaterial-based novel drug delivery systems. In addition, we briefly discuss the advantages and notable functions that make these nanomaterials suitable for the design of new medicines; the biosafety of each material discussed in this article is also highlighted to provide a comprehensive understanding of their adjuvant attributes.
摘要
得益于过去几十年纳米技术领域的发展，越来越多的生物安全纳米材料可作为医学研究中的药物佐剂使用。纳米材料具有独特的性质，可以开发出具有更长循环时间、更高载药量、更好生理条件下稳定性、控制药物释放和靶向药物递送的药物载体。在这篇综述文章中，我们将回顾代表性的有机、无机和混合生物安全纳米材料在药物研究中的应用进展，特别是关注基于纳米材料的新型药物传递系统。此外，我们还简要讨论了使这些纳米材料适合设计新药的优点和显著功能；本文讨论的每种材料的生物安全性也得到了强调，以全面了解它们的佐剂特性。
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