Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China.
National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China.
Biomater Sci. 2024 Sep 25;12(19):4903-4926. doi: 10.1039/d4bm00853g.
The study of nanomaterials' nature, function, and biocompatibility highlights their potential in drug delivery, imaging, diagnostics, and therapeutics. Advancements in nanotechnology have fostered the development and application of diverse nanomaterials. These materials facilitate drug delivery and influence the immune system directly. Yet, understanding of their impact on the immune system is incomplete, underscoring the need to select materials to achieve desired outcomes carefully. In this review, we outline and summarize the distinctive characteristics and effector functions of inorganic nanomaterials and organic materials in inducing immune responses. We highlight the role and advantages of nanomaterial-induced immune responses in the treatment of immune-related diseases. Finally, we briefly discuss the current challenges and future opportunities for disease treatment and clinical translation of these nanomaterials.
纳米材料的性质、功能和生物相容性研究突出了它们在药物输送、成像、诊断和治疗方面的潜力。纳米技术的进步促进了各种纳米材料的发展和应用。这些材料促进了药物的输送，并直接影响免疫系统。然而，人们对它们对免疫系统的影响了解还不完全，这突出表明需要仔细选择材料以达到预期的效果。在这篇综述中，我们概述和总结了无机纳米材料和有机材料诱导免疫反应的独特特征和效应功能。我们强调了纳米材料诱导的免疫反应在治疗免疫相关疾病中的作用和优势。最后，我们简要讨论了这些纳米材料在疾病治疗和临床转化方面的当前挑战和未来机遇。
