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基于珊瑚骨架的用于骨组织工程的磁性、大孔/介孔生物活性玻璃的合成。

Synthesis of magnetic, macro/mesoporous bioactive glasses based on coral skeleton for bone tissue engineering.

作者信息

Bian Chunhui, Lin Huiming, Zhang Feng, Ma Jie, Li Fengxiao, Wu Xiaodan, Qu Fengyu

机构信息

Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.

出版信息

IET Nanobiotechnol. 2014 Dec;8(4):275-81. doi: 10.1049/iet-nbt.2013.0056.

Abstract

The magnetic and macro/mesoporous bioactive glasses scaffolds are synthesised successfully by the combination of coral and P123 as co-templates through an evaporation-induced self-assembly process. The prepared material can induce the precipitation of hydroxyapatite layers on their surface in SBF only within 12 h. At the same time, the material exhibited excellent super-paramagnetic and mechanical property. Furthermore, the biocompatible assessment confirmed that the obtained material presented the good biocompatibility and the enhanced adherence of HeLa cells. Herein, the novel materials are expected to have potential application for bone tissue engineering.

摘要

通过以珊瑚和P123作为共模板,利用蒸发诱导自组装过程成功合成了磁性和大孔/介孔生物活性玻璃支架。所制备的材料仅在12小时内就能在模拟体液(SBF)中诱导其表面形成羟基磷灰石层。同时,该材料表现出优异的超顺磁性和机械性能。此外,生物相容性评估证实所获得的材料具有良好的生物相容性以及增强的HeLa细胞黏附性。在此,这种新型材料有望在骨组织工程中具有潜在应用。

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