Han Xiao, Lin Huiming, Chen Xiang, Li Xin, Guo Gang, Qu Fengyu
College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
IET Nanobiotechnol. 2016 Apr;10(2):45-53. doi: 10.1049/iet-nbt.2014.0053.
A novel three-dimensional (3D) titanium (Ti)-doping meso-macroporous bioactive glasses (BGs)/poly(methyl methacrylate) (PMMA) composite was synthesised using PMMA and EO20PO70EO20 (P123) as the macroporous and mesoporous templates, respectively. Unlike the usual calcination method, the acid steam technique was used to improve the polycondensation of Ti-BGs, and then PMMA was partially extracted via chloroform to induce the macroporous structure. Simultaneously, the residual PMMA which remained in the wall enhanced the compressive strength to 2.4 MPa (0.3 MPa for pure BGs). It is a simple and green method to prepare the macro-mesoporous Ti-BGs/PMMA. The materials showed the 3D interconnected hierarchical structure (250 and 3.4 nm), making the fast inducing-hydroxyapatite growth and the controlled drug release. Besides mentioned above, the good antimicrobial property and biocompatible of the scaffold also ensure it is further of clinical use. Herein, the fabricated materials are expected to have potential application on bone tissue regeneration.
以聚甲基丙烯酸甲酯（PMMA）和EO20PO70EO20（P123）分别作为大孔和介孔模板，合成了一种新型的三维（3D）钛（Ti）掺杂介孔-大孔生物活性玻璃（BGs）/聚甲基丙烯酸甲酯（PMMA）复合材料。与常规的煅烧方法不同，采用酸蒸汽技术促进Ti-BGs的缩聚反应，然后通过氯仿部分萃取PMMA以诱导形成大孔结构。同时，残留在壁中的PMMA将抗压强度提高到了2.4 MPa（纯BGs为0.3 MPa）。这是一种制备大孔-介孔Ti-BGs/PMMA的简单且绿色的方法。该材料呈现出三维相互连接的分级结构（250和3.4 nm），有利于快速诱导羟基磷灰石生长并实现药物的可控释放。除此之外，支架良好的抗菌性能和生物相容性也确保了其在临床上的进一步应用。在此，所制备的材料有望在骨组织再生方面具有潜在应用。
